181073-42-7

Basic information

• Product Name: 3-(6-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-ethoxy-hexanoic acid tert-butyl ester
• Synonyms: 3-(6-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-ethoxy-hexanoic acid tert-butyl ester
• CAS NO: 181073-42-7
• Molecular Weight: 467.605
• Mol File: 181073-42-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(6-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-ethoxy-hexanoic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(6-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-ethoxy-hexanoic acid tert-butyl ester(181073-42-7)
• EPA Substance Registry System: 3-(6-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-ethoxy-hexanoic acid tert-butyl ester(181073-42-7)

Safety Data

• Hazardous Substances Data: 181073-42-7(Hazardous Substances Data)

Upstream product

• 74786-02-0 1-(tert-butyldimethylsilyloxy)-1-tert-butoxyethylene 
• 181073-36-9 6-Benzyloxy-2-(4-ethoxy-1-methoxy-butyl)-3,4-dihydro-2H-isoquinolin-1-one 
• 14077-66-8 4-ethoxy-butyryl chloride 
• 181073-30-3 6-Benzyloxy-2-(4-ethoxy-butyryl)-3,4-dihydro-2H-isoquinolin-1-one 
• 164147-66-4 6-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one 

Downstream Products

• 181073-57-4 3-[6-(4-Cyano-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-6-ethoxy-hexanoic acid tert-butyl ester 
• 181073-64-3 3-{6-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-6-ethoxy-hexanoic acid tert-butyl ester 

Relevant articles and documents

An acyliminium ion approach towards the synthesis of β-substituted 3,4-dihydroisoquinolone propionates

A variety of α-methoxy amides were prepared either by selective reduction of the exocyclic carbonyl of a 2-acyl-3,4-dihydroisoquinolone and subsequent trapping of the resultant α-hydroxy amide with acidic methanol or by reacting the sodium salt of 3,4-dihydroisoquinolone with a functionalized α-chloro ether. These intermediates were reacted with 1-tert-butoxy-1-tert-butyldimethylsiloxy ethene in the presence of BF3·Et2O providing access to β-substituted isoquinolone propionates in good yield.