181188-34-1Relevant articles and documents
Facile syntheses of aryldifluorophosphonate building blocks
Cockerill, G. Stuart,Easterfield, Howard J.,Percy, Jonathan M.
, p. 2601 - 2604 (1999)
The copper-catalysed zinc phosphonate chemistry described by Yokomatsu and Shibuya can be used directly in the synthesis of phosphotyrosine analogue F2Pmp, and in entering the classical organometallic coupling repertoire via Stille and Suzuki-M
Synthesis and biological evaluation of α,α-difluorobenzylphosphonic acid derivatives as small molecular inhibitors of protein-tyrosine phosphatase 1B
Yokomatsu, Tsutomu,Murano, Tetsuo,Umesue, Ikuko,Soeda, Shinji,Shimeno, Hiroshi,Shibuya, Shiroshi
, p. 529 - 532 (2007/10/03)
A series of α,α-difluorobenzylphosphonic acids having a hydrophobic functional group were prepared via the Stille coupling reaction from halogenated α,α-difluorobenzylphosphonates. Evaluation of inhibitory activity toward protein tyrosine phosphatase (PTP 1B) revealed that the ethynyl, phenylethynyl and (E)-styryl groups on the benzene nuclei increased the inhibitory activity of α,α-difluorobenzylphosphonic acid. Inhibitory activities significantly increased upon introducing both (E)-styryl and bis- methylsulfonamide functional groups onto the benzene nuclei of α,α- difluorobenzylphosphonic acid.
