181257-35-2 Usage
Description
BIS(2-FURYL)CHLOROPHOSPHINE is an organic compound with the chemical formula C10H7ClO2P. It is a phosphine derivative that features a chlorine atom and two furyl groups attached to the phosphorus atom. BIS(2-FURYL)CHLOROPHOSPHINE is known for its reactivity and is commonly used as a building block in the synthesis of various organic compounds and ligands.
Uses
Used in Pharmaceutical Industry:
BIS(2-FURYL)CHLOROPHOSPHINE is used as a reactant for the synthesis of centrostereogenic 1,3-bidentate ferrocenyldiphosphane ligands. These ligands are essential in the development of chiral catalysts, which play a crucial role in the pharmaceutical industry for the production of enantiomerically pure drugs.
Used in Chemical Synthesis:
BIS(2-FURYL)CHLOROPHOSPHINE is used as a reactant for the synthesis of ferrocene-based chiral diphosphine compounds. These compounds are valuable in various chemical reactions and can be used to create novel materials with specific properties.
Used in Amino Acid Synthesis:
BIS(2-FURYL)CHLOROPHOSPHINE is used as a reactant for the synthesis of phosphine-containing amino acids. These amino acids can be incorporated into peptides and proteins, potentially leading to new biological activities and applications in the fields of medicine and biotechnology.
Used in Organic Chemistry:
BIS(2-FURYL)CHLOROPHOSPHINE is used as a reactant for α-arylation of aldehydes, a reaction that involves the formation of a carbon-carbon bond between an aldehyde and an aryl group. This reaction is important in the synthesis of various organic compounds, including pharmaceuticals and natural products.
Used in Stereoselective Reactions:
BIS(2-FURYL)CHLOROPHOSPHINE is used in stereoselective [2,3] sigmatropic rearrangement of acyclic allylic phosphinites. This reaction is a powerful tool in organic chemistry for the synthesis of complex molecules with specific stereochemistry, which is essential for the development of effective drugs and other bioactive compounds.
Used in Hydrophosphination Reactions:
BIS(2-FURYL)CHLOROPHOSPHINE is used as a reactant for hydrophosphination of functionalized alkenes. This reaction involves the addition of a phosphine group to an alkene, leading to the formation of phosphorus-containing compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 181257-35-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,2,5 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 181257-35:
(8*1)+(7*8)+(6*1)+(5*2)+(4*5)+(3*7)+(2*3)+(1*5)=132
132 % 10 = 2
So 181257-35-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H6ClO2P/c9-12(7-3-1-5-10-7)8-4-2-6-11-8/h1-6H
181257-35-2Relevant articles and documents
Heterocycle-substituted phosphinesulfonato palladium(II) complexes for insertion copolymerization of methyl acrylate
Jian, Zhongbao,Wucher, Philipp,Mecking, Stefan
, p. 2879 - 2888 (2014)
A family of heterocycle-substituted binuclear phosphinesulfonato Pd(II) complexes {[R2P(C6H4SO2O)] PdMeClLi(dmso)}2 (1a-d-LiCl-dmso: 1a-LiCl-dmso, R = 2-furyl; 1b-LiCl-dmso, R = 2-thienyl; 1c-LiCl-dms
Palladium-catalyzed C3-benzylation of indoles
Zhu, Ye,Rawal, Viresh H.
supporting information; experimental part, p. 111 - 114 (2012/03/07)
A general method for regioselective C3-benzylation of indoles has been developed. Various 3-substituted indoles and benzyl methyl carbonates with different electronic properties react under mild conditions to afford a diverse range of 3-benzylindolenine products in good yields.
