18158-68-4Relevant articles and documents
Anti-migration and Combustion Catalytic Performances of Ferrocenyl Compounds of Anilines and Alkylamines Synthesized by Click Reaction
Shi, Xiaoling,Cheng, Wenqian,Jiang, Liping,Bi, Fuqiang,Li, Jizhen,Zhang, Guofang
, p. 463 - 470 (2020/10/21)
To enhance anti-migratory performance and combustion catalytic activities of neutral ferrocene-based burning rate catalysts (BRCs), nine ferrocenyl 1,2,3-triazolyl compounds of anilines and aliphatic amines (Fc-ATAZs, 1–9) were synthesized by click reaction and characterized by NMR, UV/Vis, FT-IR, and MS. TG and DSC studies confirmed that the Fc-ATAZs are highly thermal stable. Cyclic voltammetry results implied that 1 and 6 are reversible redox systems. The anti-migration and anti-volatility tests showed that the Fc-ATAZs are low-migratory and low-volatile compounds.Combustion catalytic activity results of the Fc-ATAZs revealed that they are highly active for promoting thermal disintegration of AP, RDX and HMX. Compounds 3, 2 and 8 can increase released heats of AP, RDX and HMX, respectively, by 132 %, 112 % and 36 %, respectively, being the highest in each case. Most of them are more active than the reported analogs derived from phenols and benzoic acids. They, except 9, are more active than catocene and can be used as potential BRCs in composite solid propellants.
Pyridoxine-resveratrol hybrids as novel inhibitors of MAO-B with antioxidant and neuroprotective activities for the treatment of Parkinson's disease
Cao, Zhongcheng,Deng, Yong,Li, Wei,Shi, Yichun,Song, Qing,Yang, Xia,Zhang, Li
, (2020/03/10)
A series of pyridoxine-resveratrol hybrids were designed and synthesized as monoamine oxidase B inhibitors for the treatment of Parkinson's disease. Most of them exhibited potent inhibitory activities on MAO-B with high selectivity. Specifically, compounds 12a, 12g and 12l showed the most excellent inhibition to hMAO-B with the IC50 values of 0.01 μM, 0.01 μM and 0.02 μM, respectively. Further reversibility study demonstrated that 12a and 12l were reversible and 12g was irreversible MAO-B inhibitors. Molecular docking studies of MAO revealed the binding mode and high selectivity of these compounds with MAO-B. In addition, these three representative compounds also exhibited low cytotoxicity and excellent neuroprotective effect in the test on H2O2-induced PC-12 cell injury. Moreover, 12a, 12g and 12l showed good antioxidant activities and high blood-brain barrier permeability. Overall, all of these results highlighted 12a, 12g and 12l were potential and excellent MAO-B inhibitors for PD treatment.
One-pot synthesis of novel N,N-bis(isoxazol-5-yl)methyl tertiary arylamines via sequential diprop-3-ynylation and 1,3-dipolar cycloaddition from primary amines
Zhang, Xiao-Lan,Wei, Mei-Hong,Sheng, Shou-Ri,Liu, Xiao-Ling
, p. 407 - 411 (2019/09/03)
A simple and efficient one-pot multicomponent approach for the synthesis of tertiary arylamines bearing N,N-bis(isoxazol-5-yl)methyl groups is developed through reactions including sequential diprop-3-ynylation of primary amines with propargyl bromide in
