181622-66-2

Basic information

• Product Name: (S)-2-[3-((S)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester
• CAS NO: 181622-66-2
• Molecular Weight: 565.621
• Mol File: 181622-66-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[3-((S)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[3-((S)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester(181622-66-2)
• EPA Substance Registry System: (S)-2-[3-((S)-4-tert-Butoxycarbonylamino-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester(181622-66-2)

Safety Data

• Hazardous Substances Data: 181622-66-2(Hazardous Substances Data)

Upstream product

• 59279-58-2 N^α-tert-butyloxycarbonyl-γ-benzyloxycarbonyl-L-glutamic acid methyl ester 
• 13574-13-5 Boc-Glu(OBzl)-OH 
• 72086-72-7 N-tert-butoxycarbonylglutamic acid methyl ester 

Downstream Products

• 181622-90-2 (S)-2-[3-((S)-4-{4-[2-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butyrylamino)-benzoylamino]-pentanedioic acid diethyl ester 

Relevant articles and documents

Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. II. Synthesis and antitumor activity of N5-substituted glutamine analogs

The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3- d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid (1b, TNP-351) and related compounds was replaced with some N5-substituted glutamines. Antifolates (4A-S) were effectively prepared