181641-53-2

Basic information

• Product Name: Formamide, N-[4-phenyl-1-(phenylmethyl)-4-piperidinyl]-
• CAS NO: 181641-53-2
• Molecular Formula: C19H22N2O
• Molecular Weight: 294.396
• Mol File: 181641-53-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Formamide, N-[4-phenyl-1-(phenylmethyl)-4-piperidinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N-[4-phenyl-1-(phenylmethyl)-4-piperidinyl]-(181641-53-2)
• EPA Substance Registry System: Formamide, N-[4-phenyl-1-(phenylmethyl)-4-piperidinyl]-(181641-53-2)

Safety Data

• Hazardous Substances Data: 181641-53-2(Hazardous Substances Data)

Upstream product

• 591-51-5 phenyllithium 
• 63843-83-4 1-benzyl-4-hydroxy-4-phenylpiperidine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 181641-49-6 1-benzyl-4-phenylpiperidin-4-ylamine 
• 109-94-4 formic acid ethyl ester 
• 7677-24-9 trimethylsilyl cyanide 
• 172733-78-7 N-(1-benzyl-4-phenylpiperidin-4-yl)acetamide 

Downstream Products

• 182621-57-4 {3-(3,4-Dichloro-phenyl)-3-[3-(4-methylamino-4-phenyl-piperidin-1-yl)-propyl]-piperidin-1-yl}-phenyl-methanone 
• 182621-56-3 4-methylamino-4-phenylpiperidine 
• 172734-92-8 (S)-(N)-(1-(3-(1-benzoyl-3(3,4-dichlorophenyl)piperidin-3-yl)propyl)-4-phenylpiperidin-4-yl)-N-methylacetamide 
• 172734-92-8 osanetant 
• 188916-70-3 N-Methyl-N-(4-phenyl-piperidin-4-yl)-acetamide; hydrochloride 
• 172734-03-1 1-Benzyl-4-(methylamino)-4-phenylpiperidine 

Relevant articles and documents

SUBSTITUTED HETEROCYCLIC COMPOUNDS METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT

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A practical and scalable synthesis of SR 142801, a tachykinin NK3 antagonist

A practical and scalable total synthesis of tachykinin NK3 receptor antagonist SR 142801, (R)-N-[1-[3-[1-benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-4 -piperidinyl]-N-methyl acetamide 1 is described. The absolute configuration of the key intermediate 7 was determined by single crystal X-ray crystallography, on the basis of which, the absolute configuration of SR 142801 should be (R)-(+), instead of the recently reported (S)-(+).

A novel modification of the Ritter reaction using trimethylsilyl cyanide

A new modification of the Ritter reaction using trimethylsilyl cyanide (Me3SiCN) is described, which converts alcohols to their corresponding formamides in high yields using a convenient procedure. The reaction conditions and mechanism are discussed. In some cases, new formamides are synthesized which cannot be prepared by the classical Ritter reaction.