1819-80-3

Basic information

• Product Name: Thiourea, N-(6-methyl-2-benzothiazolyl)-N'-phenyl-
• CAS NO: 1819-80-3
• Molecular Formula: C15H13N3S2
• Molecular Weight: 299.42
• Mol File: 1819-80-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Thiourea, N-(6-methyl-2-benzothiazolyl)-N'-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N-(6-methyl-2-benzothiazolyl)-N'-phenyl-(1819-80-3)
• EPA Substance Registry System: Thiourea, N-(6-methyl-2-benzothiazolyl)-N'-phenyl-(1819-80-3)

Safety Data

• Hazardous Substances Data: 1819-80-3(Hazardous Substances Data)

Upstream product

• 2536-91-6 6-methylbenzothiazol-2-ylamine 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 140190-24-5 {Mn(C₆H₅NC(S)NH(C₇H₃NSCH₃))2(H₂O)2} 
• 108718-01-0 N-phenyl-N'-(6-methylbenzothiazol-2-yl)urea 
• 110274-35-6 (6-methyl-benzothiazol-2-yl)-phenyl-carbodiimide 
• 5923-86-4 N-(6-methyl-benzothiazol-2-yl)-N'-phenyl-guanidine 
• 24106-81-8 N-benzyl-N'-(6-methyl-benzothiazol-2-yl)-N''-phenyl-guanidine 
• 72128-89-3 N-(6-methyl-benzothiazol-2-yl)-N'-phenyl-N''-propyl-guanidine 

Relevant articles and documents

Synthesis and cytotoxic evaluation of thiourea and N-bis-benzothiazole derivatives: A novel class of cytotoxic agents

Benzothiazolyl thiocarbamides has been achieved using a catalytic amount of 4-dimethylaminopyridine (DMAP) followed by its chemoselective oxidative cyclization with 1,3-di-n-butylimidazolium tribromide[bbim][Br3] to afford the N-bis-benzothiazole derivatives. All the synthesized compounds were evaluated for cytotoxic activity against two human monocytic cell lines (U 937, THP-1) and a mouse melanoma cell line (B16-F10). Based on their IC50 values, the majority of the benzothiazolyl thiocarbamides and N-bis-benzothiazoles had significant antiproliferative activity on U 937 and B16-F10 cells, the compounds 3b, 3e, 3f, 3k, 6c and 6h were found to be the most active. The present findings indicate clearly that the compound 3e exhibited more antiproliferative activity on U 937 cells than the standard molecule, etoposide. Nevertheless, these compounds have shown comparatively less cytotoxicity towards THP-1 cells.