18197-26-7 Usage
Description
DIFORMYLIMIDE SODIUM SALT is an organic compound with a slightly beige powder appearance, known for its versatile applications in various industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
DIFORMYLIMIDE SODIUM SALT is used as a reactant for the preparation of functionalized condensed benzazoles, which are significant in the development of α-ketoheterocycles. These heterocycles act as inhibitors of Leishmania mexicana cysteine protease CPB, a crucial enzyme in the survival and pathogenesis of Leishmania parasites.
Used in Chemical Synthesis:
DIFORMYLIMIDE SODIUM SALT is utilized as a key intermediate in the synthesis of BINOLand H8-BINOL-based aryl phosphites. These phosphites serve as efficient ligands in palladium-catalyzed asymmetric allylation and amination reactions, which are essential processes in the production of various pharmaceuticals and agrochemicals.
Used in Antibiotic Resistance:
In the field of antibiotic resistance, DIFORMYLIMIDE SODIUM SALT is used as a precursor for the development of β-lactamase AmpC inhibitor analogues. These analogues exhibit improved cell permeability properties, enhancing their effectiveness in combating antibiotic-resistant bacteria.
Used in Enzyme Inhibition:
DIFORMYLIMIDE SODIUM SALT is employed in the synthesis of inhibitors targeting PHA-399733 via the Bucherer-Bergs hydantoin synthesis method. These inhibitors play a vital role in regulating enzyme activity, which can be beneficial in various therapeutic applications.
Used in Biochemical Research:
As a precursor, DIFORMYLIMIDE SODIUM SALT is used in the development of αVβ3 integrin antagonists. These antagonists are crucial in studying and understanding the role of integrins in various biological processes, including cell adhesion, migration, and angiogenesis.
Purification Methods
Grind the amide under dry tetrahydrofuran (fumehood), filter and wash it with this solvent, then dry it in vacuo. It is soluble in EtOH and H2O but insoluble in Et2O and pet ether. [IR and preparation: Rakshit J Chem Soc 103 1557 1913, Yinglin & Hongwen Synthesis 122 1990, Allenstein & Beyl Chem Ber 100 355 1967, Allenstein et al. Chem Ber 102 4089 1969, Beilstein 2 II 22.]
Check Digit Verification of cas no
The CAS Registry Mumber 18197-26-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,1,9 and 7 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18197-26:
(7*1)+(6*8)+(5*1)+(4*9)+(3*7)+(2*2)+(1*6)=127
127 % 10 = 7
So 18197-26-7 is a valid CAS Registry Number.
InChI:InChI=1/C2H3NO2.Na/c4-1-3-2-5;/h1-2H,(H,3,4,5);/q;+1/p-1
18197-26-7Relevant articles and documents
Simple and Efficient Process for the Large-Scale Preparation of Agomelatine: An Antidepressant Drug
Vujjini, Satish Kumar,Vyala, Sunitha,Badarla, Krishna Rao,Kandala, Sreenatha Charyulu,Bandichhor, Rakeshwar,Kagga, Mukkanti,Cherukupalli, Praveen
supporting information, p. 1864 - 1870 (2015/08/03)
A simple and efficient process for the large-scale preparation of agomelatine (1), an antidepressant drug is, described. Agomelatine was prepared in a linear manner starting from readily available, inexpensive 2-naphthol. Key steps in the synthesis are Friedel-Crafts acylation of 2-naphthyl acetate with chloroacetyl chloride, reduction of keto intermediate, and nucleophilic displacement of chloro intermediate with sodium diformylamide. A systemic approach was described to streamline the process into a robust scalable process by controlling the impurities.
Salts and ionic liquids of resonance stabilized amides
Brand, Harald,Martens, Joern,Mayer, Peter,Schulz, Axel,Seibald, Markus,Soller, Thomas
experimental part, p. 1588 - 1603 (2010/06/20)
The synthesis, structure, and bonding of alkali salts of resonance stabilized amides, such as diformylamide (dfa), formylcyanoamide (fca), nitrocyanoamide (nca), and for comparision, the well-known dicyanoamide (dca), are discussed on the basis of experim
Highly regio- and enantioselective palladium-catalyzed allylic amination with sodium diformylamide
Wang,Ding
, p. 3238 - 3241 (2007/10/03)
-