181997-31-9

Basic information

• Product Name: Acetamide, N-[[(5S)-3-(4-amino-3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl]-
• CAS NO: 181997-31-9
• Molecular Formula: C12H14FN3O3
• Molecular Weight: 267.26
• Mol File: 181997-31-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[[(5S)-3-(4-amino-3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[[(5S)-3-(4-amino-3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl]-(181997-31-9)
• EPA Substance Registry System: Acetamide, N-[[(5S)-3-(4-amino-3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl]-(181997-31-9)

Safety Data

• Hazardous Substances Data: 181997-31-9(Hazardous Substances Data)

Upstream product

• 219664-14-9 N-(4-amino-2-fluorophenyl)-N-benzylamine 
• 181997-28-4 N-benzyl-2-fluoro-4-nitroaniline 
• 181997-30-8 benzyl benzyl{2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}carbamate 
• 219664-23-0 benzyl 4-((S)-5-(aminomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenylbenzylcarbamate 
• 181997-29-5 benzyl benzyl(4-{[(benzyloxy)carbonyl]amino}-2-fluorophenyl)carbamate 
• 219664-27-4 Methanesulfonic acid (R)-3-[4-(benzyl-benzyloxycarbonyl-amino)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl ester 
• 324789-15-3 5-(S)-Aminomethyl-3-[4'-(tert-butoxycarbonyl)amino-3'-fluorophenyl]-oxazolidine-2-one 
• 851529-79-8 benzyl-[4-(5-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluoro-phenyl]-carbamate 
• 183905-31-9 N-[(2S)-2-acetoxy-3-chloropropyl]acetamide 
• 219664-11-6 Benzyl-{4-[(S)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-carbamic acid benzyl ester 
• 369-34-6 3,4-difluoronitrobenzene 
• 182059-57-0 benzyl 4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl(benzyl)carbamate 

Downstream Products

• 181996-88-3 N-{(S)-3-[3-fluoro-4-(3-formyl-pyrrol-1-yl)-phenyl]-2-oxo-oxazolidin-5-yl methyl}-acetamide 
• 220010-58-2 N-[[(5S)-3-[3-fluoro-4-nitrile-phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide 
• 266327-76-8 N-{3-[3-fluoro-4-(3-hydroxy-pyrazol-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 266328-00-1 N-{3-[4-(3-amino-[1,2,4]triazol-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 266328-03-4 N-{3-[3-fluoro-4-(5-formyl-tetrazol-2-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 181996-95-2 N-{3-[3-fluoro-4-(4-formyl-[1,2,3]triazol-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 226220-44-6 (S)-N-[[3-[3-fluoro-4-(3-(methoxyiminomethyl)-1H-pyrrol-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 266327-89-3 N-{3-[3-fluoro-4-(3-hydroxymethyl-[1,2,4]triazol-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 181996-85-0 (S)-N-[[3-[4-[3-mercapto-4-[1,2,4]triazolyl]-3-fluorophenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 

Relevant articles and documents

Oxazolidinones compound and application thereof

The invention provides an oxazolidinones compound shown as the formula VI, or salt, an aquo-complex, or a crystal form of the oxazolidinones compound, which are pharmaceutically acceptable. The invention also provides a preparation method of the compound. In the current field of a chemical drug, activity of most compounds with changed structures becomes better, while toxicity is obviously enhanced, so that the compounds cannot be used as drugs. Compared with a compound in the prior art, the oxazolidinones compound provided in the invention has excellent anti-drug-resistance and antimicrobial activity. What is unexpected is that the oxazolidinones compound has better safety and benefits safe drug use and therapy of a patient.

OXAZOLIDINONE COMPOUNDS AND THEIR USES IN PREPARATION OF ANTIBIOTICS

The invention belongs to the field of medicaments, and particularly relates to oxazolidinone compounds and their uses in the preparation of antibiotics. A technical problem to be solved by the invention is to provide new oxazolidinone compounds having the structure represented by Formula I. The oxazolidinone compounds of the invention, which are new compounds obtained through numerous screening, have significant antibacterial activity against bacteria such as drug-resistant staphylococcus aureus, fecal coliform bacteria, and streptococcus pneumoniae, while exhibiting low toxicity. The invention provides new options for the development and application of antibiotics.

ANTIMICROBIAL 1-ARYL DIHYDROPYRIDONE COMPOUNDS

The present invention provides antibacterial agents of formula (I), or a pharmaceutically acceptable salt thereof, wherein A is a structure (i), (ii), (iii) or (iv); X is (a) NHC(=O)R1, (b) NHC(=S)R1, (c) NH-het1/sup