18208-28-1

Basic information

• Product Name: Cycloheptan-carbonsaeure-anilid
• CAS NO: 18208-28-1
• Molecular Weight: 217.311
• Mol File: 18208-28-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cycloheptan-carbonsaeure-anilid(CAS DataBase Reference)
• NIST Chemistry Reference: Cycloheptan-carbonsaeure-anilid(18208-28-1)
• EPA Substance Registry System: Cycloheptan-carbonsaeure-anilid(18208-28-1)

Safety Data

• Hazardous Substances Data: 18208-28-1(Hazardous Substances Data)

Upstream product

• 14088-64-3 2-Diazacyclooctanone 
• 62-53-3 aniline 
• 1459-36-5 2-oxo-cyclooctanecarbaldehyde 
• 1428045-84-4 C₈H₁₄OS 
• 51034-34-5 potassium aniline dithiocarbamate 

Relevant articles and documents

A traceless approach to amide and peptide construction from thioacids and dithiocarbamate-terminal amines

A novel and traceless strategy has been devised that allows a coupling of thioacids and dithiocarbamate-terminal amines. This strategy had been assumed to be dependent on the attachment of a functional equivalent of a cysteine side chain in earlier native chemical ligation approaches. This approach enables the traceless removal of CS2 to directly generate the desired amide bond and is compatible with a range of unprotected side chains of amino acid. The ability to produce amide or peptides by a traceless removal of the auxiliary is a significant virtue of the method. Meanwhile, the application of this new peptide-bond-forming reaction to the synthesis of novel endomorphin (EM) derivatives with various binding potencies was realized.