18220-90-1

Basic information

• Product Name: 4-ETHYLBENZOPHENONE
• Synonyms: Methanone, (4-ethylphenyl)phenyl-;4-ETHYLBENZOPHENONE
• CAS NO: 18220-90-1
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 210.27
• EINECS: 242-101-4
• Product Categories: Aromatic Benzophenones & Derivatives (substituted)
• Mol File: 18220-90-1.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 150°C 0,5mm
• Flash Point: >110°C
• Appearance: /
• Density: 1.0232 (rough estimate)
• Vapor Pressure: 9.04E-05mmHg at 25°C
• Refractive Index: 1.5935
• Water Solubility: Insoluble in water.
• BRN: 1949192
• CAS DataBase Reference: 4-ETHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHYLBENZOPHENONE(18220-90-1)
• EPA Substance Registry System: 4-ETHYLBENZOPHENONE(18220-90-1)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 18220-90-1(Hazardous Substances Data)

Usage

Description

4-Ethylbenzophenone is an organic compound with the chemical formula C6H5COC6H4CH3. It is a derivative of benzophenone, featuring an ethyl group attached to the para position of the phenyl ring. 4-ETHYLBENZOPHENONE is known for its potential applications in various chemical and pharmaceutical processes due to its unique structure and properties.

Uses

Used in Pharmaceutical Industry:
4-Ethylbenzophenone is used as an intermediate in the synthesis of various pharmaceutical compounds. Its ability to form stable complexes with metal catalysts makes it a valuable component in the development of new drugs and drug delivery systems.
Used in Chemical Industry:
4-Ethylbenzophenone is used in the preparation of crystal structures of biphenyl palladium azacyclic carbene complex catalysts. These catalysts are essential in the synthesis of (phenyl)(aryl)methanone via acylative Suzuki coupling, a widely used method in organic chemistry for the formation of carbon-carbon bonds.

InChI:InChI=1/C15H20O/c1-2-12-8-10-14(11-9-12)15(16)13-6-4-3-5-7-13/h8-11,13H,2-7H2,1H3

Upstream product

• 100-41-4 ethylbenzene 
• 455-32-3 benzoyl fluoride 
• 98-88-4 benzoyl chloride 
• 74-96-4 ethyl bromide 
• 2042-85-5 1,2-diphenylpropan-1-one 
• 951-85-9 (S)-methyldesoxybenzoin 
• 17988-51-1 1-Ethyl-3-trimethylsilylbenzol 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 75-03-6 ethyl iodide 
• 6136-66-9 4-iodobenzophenone 
• 119-61-9 benzophenone 
• 64-17-5 ethanol 
• 16331-45-6 p-ethylbenzoyl chloride 
• 71-43-2 benzene 

Downstream Products

• 77989-25-4 1-(4-ethyl-phenyl)-1-phenyl-ethene 
• 102891-75-8 3-(4-ethyl-phenyl)-2-(2,5-dimethyl-phenyl)-3-phenyl-acrylonitrile 
• 856365-61-2 1-(4-ethyl-phenyl)-1,1,2,2-tetraphenyl-ethane 
• 611-95-0 4-carboxybenzophenone 
• 619-64-7 p-ethylbenzoic acid 
• 22543-70-0 α-(p-ethylphenyl)-α-phenylmethanol 
• 620-85-9 1-benzyl-4-ethylbenzene 
• 809-34-7 1,2-bis-(4-ethyl-phenyl)-1,2-diphenyl-ethane-1,2-diol 
• 2301-17-9 4-ethyl-benzophenone-seqcis-oxime 
• 107225-78-5 2,5-bis-(4-benzoyl-phenyl)-thiophene 
• 102594-04-7 3-(4-ethyl-phenyl)-2,3-diphenyl-acrylonitrile 
• 79316-80-6 [4-(1-bromoethyl)phenyl](phenyl)methanone 
• 53689-84-2 4-acetylbenzophenone 
• 482620-67-7 4-(1-aminoethyl)benzophenone 

Relevant articles and documents

Friedel-Crafts Alkylation of Benzenes Substituted with Meta-Directing Groups

In protonic acids, benzaldehyde, acetophenone, benzophenone, and ethyl benzoate were ring-alkylated by alcohols.Benzonitrile was N-alkylated rather than ring-alkylated.Ethyl n-propyl, isopropyl, and n-butyl alcohol were effective alkylating agents, wherea

Mechanochemical Solvent-Free Suzuki–Miyaura Cross-Coupling of Amides via Highly Chemoselective N?C Cleavage

Although cross-coupling reactions of amides by selective N?C cleavage are one of the most powerful and burgeoning areas in organic synthesis due to the ubiquity of amide bonds, the development of mechanochemical, solid-state methods remains a major challe

Pd-Catalysed carbonylative Suzuki-Miyaura cross-couplings using Fe(CO)5under mild conditions: generation of a highly active, recyclable and scalable ‘Pd-Fe’ nanocatalyst

The dual function and role of iron(0) pentacarbonyl [Fe(CO)5] has been identified in gaseous CO-free carbonylative Suzuki-Miyaura cross-couplings, in which Fe(CO)5supplied COin situ, leading to the propagation of catalytically active Pd-Fe nanoparticles. Compared with typical carbonylative reaction conditions, CO gas (at high pressures), specialised exogenous ligands and inert reaction conditions were avoided. Our developed reaction conditions are mild, do not require specialised CO high pressure equipment, and exhibit wide functional group tolerance, giving a library of biaryl ketones in good yields.

Method for selectively synthesizing benzyl trifluoromethyl sulfide

The invention discloses a method for selectively synthesizing benzyl trifluoromethyl sulfide. The method comprises the following steps: taking alkyl aromatic hydrocarbon ArCHR1R2 as a raw material; and under irradiation by a blue light lamp, in a solution, under the argon atmosphere and under presence of a small amount of potassium carbonate, taking 4CzIPN as a photocatalyst to react with 2-((trifluoromethyl) sulfenyl)isoindoline-1, 2, 3, 4-thiadiazole to obtain photocatalyst 4CzIPN shown in the benzyl trifluoromethyl sulfide ArCR1R2SCF3 (3), wherein the photocatalyst 4CzIPN has the followingstructure shown in the specification. According to the method, the reaction conditions are mild, no oxidizing agent or high-temperature condition is needed, residues of transition metal are avoided, and benzyl trifluoromethyl sulfide is directly obtained from alkyl arene and trifluoromethyl sulfide reagents which are stable and easy to obtain.