182205-76-1Relevant articles and documents
Total synthesis of the antifungal cyclic depsipeptides Sch 57697 and aureobasidin A
Jao, Edwin,Cooper, Alan B.,Rane, Dinanath F.,Saksena, Anil K.,Desai, Jagdish,Wang, James,Girijavallabhan, Viyyoor M.,Ganguly, Ashit K.
, p. 5661 - 5664 (1996)
A novel cyclic depsinonapeptide antifungal 1a (Sch 57697) and its isomer 1b were synthesized by a fragment coupling approach and this methodology was applied to the total synthesis of the natural product aureobasidin A. Synthetic strategies for coupling of N-methyl amino acids with minimal racemization are discussed. Biological evaluation of isomers 1a and 1b demonstrated the importance of chirality at the β-hydroxy-N-methylvaline (OHMeVal) position.