182223-09-2Relevant articles and documents
Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazolone derivatives
Schaus, John M.,Thompson, Dennis C.,Bloomquist, William E.,Susemichel, Alice D.,Calligaro, David O.,Cohen, Marlene L.
, p. 1943 - 1955 (1998)
A series of indole-3-carboxamides, indazole-3-carboxamides, and benzimidazolone-3-carboxamides was synthesized and evaluated for antagonist affinity at the 5-HT4 receptor in the rat esophagus. The endo-3-tropanamine derivatives in the indazole
Indazolecarboxamides
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, (2008/06/13)
Indazolecarboxamides are used as antagonists and partial agonists for the serotonin receptor 5-HT 4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT 4 receptor.