182223-53-6

Basic information

• Product Name: 1-Benzyl-4-benzyloxycarbonylaminopiperidine
• Synonyms: 1-Benzyl-4-benzyloxycarbonylaminopiperidine;4-(Cbz-aMino)-1-benzylpiperidine;[1-(Benzyl)-4-piperidinyl]carbaMic Acid Benzyl Ester;[1-(PhenylMethyl)-4-piperidinyl]carbaMic Acid PhenylMethyl Ester;Benzyl (1-Benzylpiperidin-4-yl)carbaMate;N-(Benzyloxycarbonyl)-1-benzylpiperidin-4- ylaMin;N-(Benzyloxycarbonyl)-1-benzylpiperidin-4-ylamine
• CAS NO: 182223-53-6
• Molecular Formula: C₂₀H₂₄N₂O₂
• Molecular Weight: 324.41676
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 182223-53-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 475.75°C at 760 mmHg
• Flash Point: 241.525°C
• Appearance: /
• Density: 1.158g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 12.14±0.20(Predicted)
• CAS DataBase Reference: 1-Benzyl-4-benzyloxycarbonylaminopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4-benzyloxycarbonylaminopiperidine(182223-53-6)
• EPA Substance Registry System: 1-Benzyl-4-benzyloxycarbonylaminopiperidine(182223-53-6)

Safety Data

• Hazardous Substances Data: 182223-53-6(Hazardous Substances Data)

Usage

Description

1-Benzyl-4-benzyloxycarbonylaminopiperidine is an organic compound that serves as an intermediate in the synthesis of various pharmaceuticals. It is characterized by its pale-yellow solid appearance and plays a crucial role in the development of p-38 kinase inhibitors and serotonin antagonists.

Uses

Used in Pharmaceutical Industry:
1-Benzyl-4-benzyloxycarbonylaminopiperidine is used as a chemical intermediate for the preparation of p-38 kinase inhibitors and serotonin antagonists. Its role in the synthesis of these compounds is vital for the development of medications targeting specific biological pathways and receptors, thereby contributing to the treatment of various diseases and conditions.

InChI:InChI=1/C20H24N2O2/c23-20(24-16-18-9-5-2-6-10-18)21-19-11-13-22(14-12-19)15-17-7-3-1-4-8-17/h1-10,19H,11-16H2,(H,21,23)

Upstream product

• 50541-93-0 4-amino-1-benzylpiperidine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 182223-52-5 1-(2-aminoethyl)-4-benzyloxycarbonylaminopiperidine 
• 182223-55-8 {1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-piperidin-4-yl}-carbamic acid benzyl ester 
• 182223-02-5 N-[2-(4-benzyloxycarbonylamino-1-piperidinyl)ethyl]-1H-indazole-3-carboxamide 
• 182223-03-6 N-[2-(4-benzyloxycarbonylamino-1-piperidinyl)ethyl]-1-(2-propyl)-1H-indazole-3-carboxamide 
• 182223-54-7 piperidin-4-ylcarbamic acid benzyl ester 
• 207296-89-7 piperidin-4-ylcarbamic acid benzyl ester hydrochloride 

Relevant articles and documents

Imidazo-substituted compounds as p38 kinase inhibitors

The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.

Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazolone derivatives

A series of indole-3-carboxamides, indazole-3-carboxamides, and benzimidazolone-3-carboxamides was synthesized and evaluated for antagonist affinity at the 5-HT4 receptor in the rat esophagus. The endo-3-tropanamine derivatives in the indazole