182244-33-3 Usage
Description
Bromoacetamido-PEG2-Boc-amine is a PEGylated molecule that features a Boc-protected amine and a bromide group. The Boc-protected amine can be deprotected under mild acidic conditions, while the bromide serves as an excellent leaving group for nucleophilic substitution reactions. The hydrophilic PEG (polyethylene glycol) spacer enhances solubility in aqueous media, making it suitable for various applications in different industries.
Uses
Used in Bioconjugation:
Bromoacetamido-PEG2-Boc-amine is used as a bioconjugation agent for the attachment of biomolecules to other molecules or surfaces. The bromide group facilitates nucleophilic substitution, allowing for the covalent linking of target biomolecules, while the PEG spacer improves solubility and stability.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Bromoacetamido-PEG2-Boc-amine is used as a component in drug delivery systems. The PEG spacer and Boc-protected amine provide opportunities for the attachment of drug molecules, enhancing their solubility, bioavailability, and therapeutic efficacy.
Used in Diagnostic Imaging:
Bromoacetamido-PEG2-Boc-amine is utilized as a contrast agent in diagnostic imaging. The PEG spacer and Boc-protected amine can be functionalized to bind with imaging agents, improving their solubility and circulation time in the body, leading to enhanced imaging capabilities.
Used in Chemical Synthesis:
In the field of chemical synthesis, Bromoacetamido-PEG2-Boc-amine serves as an intermediate or building block for the synthesis of complex molecules. The bromide group allows for nucleophilic substitution with various nucleophiles, enabling the creation of a wide range of PEGylated compounds with diverse applications.
Check Digit Verification of cas no
The CAS Registry Mumber 182244-33-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,2,2,4 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 182244-33:
(8*1)+(7*8)+(6*2)+(5*2)+(4*4)+(3*4)+(2*3)+(1*3)=123
123 % 10 = 3
So 182244-33-3 is a valid CAS Registry Number.
182244-33-3Relevant articles and documents
CHROMOGENIC PEROXIDASE SUBSTRATES
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Paragraph 0412-0413, (2017/07/14)
Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color.
Plasma-mediated release of morphine from synthesized prodrugs
Thomas, Thommey P.,Huang, Baohua,Desai, Ankur,Zong, Hong,Cheng, Xue-Min,Kotlyar, Alina,Leroueil, Pascale R.,Dunham, Thomas,Van Der Spek, Abraham,Ward, Brent B.,Baker Jr., James R.
supporting information; scheme or table, p. 6250 - 6253 (2010/12/18)
Two morphine prodrugs ('PDA' and 'PDB') were synthesized and the kinetics of esterase-mediated morphine release from these prodrugs were determined when incubated with plasma from different animal species. Morphine was rapidly released from PDA by all spe
