182245-71-2

Basic information

• Product Name: C₃₇H₄₉N₂O₉PSi₂
• CAS NO: 182245-71-2
• Molecular Weight: 752.949
• Mol File: 182245-71-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₃₇H₄₉N₂O₉PSi₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₇H₄₉N₂O₉PSi₂(182245-71-2)
• EPA Substance Registry System: C₃₇H₄₉N₂O₉PSi₂(182245-71-2)

Safety Data

• Hazardous Substances Data: 182245-71-2(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 130288-81-2 5'-O-dimethoxytrityl-2'-deoxythymidine-3'-H-phosphonate 
• 3868-27-7 triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 102987-82-6 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl methyl phosphonate 

Downstream Products

• 104655-93-8 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl S-phenyl phosphorothioate trimethylsilyl ester 

Relevant articles and documents

A facile access to nucleoside phosphorofluoridate, nucleoside phosphorofluoridothioate, and nucleoside phosphorofluoridodithioate monoesters

Oxidation of H-phosphonate, H-phosphonothioate, or H-phosphonodithioate monoesters with iodine in pyridine in the presence of trimethylsilyl chloride, followed by addition of triethylamine trishydrofluoride (TAF) furnished rapid and quantitative formation of the corresponding phosphorofluoridate, phosphorofluoridothioate, or phosphorofluoridodithioate monoesters.

Nucleoside Phosphonates: Part 7. Studies on the Oxidation of Nucleoside Phosphonate Esters

Oxidation of phosphonate mono- and di-esters with various oxidizing agents including diaryl disulphides, hexacloroacetone, and iodine, has been investigated under various reaction conditions.The most efficient oxidation procedure consists of treatment of phosphonate esters with iodine in pyridine-water.When the phosphonate esters were presilylated by treatment with trimethylsilyl chloride, the subsequent oxidation with aqueous iodine was faster. (31)P N.m.r. spectroscopic studies have enabled us to propose the most likely pathway for the majority of the oxidations.