182249-64-5

Basic information

• Product Name: (S)-2-Benzyloxycarbonylamino-3-(3-{4-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-methoxy-phenyl)-propionic acid 2-iodo-ethyl ester
• Synonyms: (S)-2-Benzyloxycarbonylamino-3-(3-{4-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-methoxy-phenyl)-propionic acid 2-iodo-ethyl ester
• CAS NO: 182249-64-5
• Molecular Weight: 890.726
• Mol File: 182249-64-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-Benzyloxycarbonylamino-3-(3-{4-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-methoxy-phenyl)-propionic acid 2-iodo-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Benzyloxycarbonylamino-3-(3-{4-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-methoxy-phenyl)-propionic acid 2-iodo-ethyl ester(182249-64-5)
• EPA Substance Registry System: (S)-2-Benzyloxycarbonylamino-3-(3-{4-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-methoxy-phenyl)-propionic acid 2-iodo-ethyl ester(182249-64-5)

Safety Data

• Hazardous Substances Data: 182249-64-5(Hazardous Substances Data)

Upstream product

• 182249-56-5 (S)-3-{(S)-2-Azido-3-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-propionyl}-4-benzyl-oxazolidin-2-one 
• 182249-60-1 (S)-2-((S)-2-tert-Butoxycarbonylamino-3-carbamoyl-propionylamino)-3-(4-chloro-phenyl)-propionic acid methyl ester 
• 182249-55-4 (S)-4-Benzyl-3-{3-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-propionyl}-oxazolidin-2-one 
• 182249-57-6 (S)-3-[(S)-2-Azido-3-(3-hydroxy-4-methoxy-phenyl)-propionyl]-4-benzyl-oxazolidin-2-one 
• 182249-49-6 (S)-2-Benzyloxycarbonylamino-3-(3-hydroxy-4-methoxy-phenyl)-propionic acid 2-bromo-ethyl ester 
• 182249-53-2 3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-propionic acid benzyl ester 
• 182249-58-7 (2S)-2-azido-3-(3-hydroxy-4-methoxyphenyl)propionic acid 2-bromoethyl ester 
• 182249-52-1 3-(3-hydroxy-4-methoxyphenyl)propionic acid benzyl ester 
• 182249-54-3 3-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-propionic acid 
• 182249-59-8 (2S)-2-azido-3-(4-chlorophenyl)propionic acid methyl ester 
• 159750-04-6 (S)-2-Azido-3-(4-chlorophenyl)propionic acid 
• 14173-40-1 (S)-2-amino-3-(4-chloro-phenyl)-propionic acid methyl ester hydrochloride 
• 1135-15-5 dihydroisoferulic acid 
• 182249-48-5 (S)-2-Benzyloxycarbonylamino-3-(3-{4-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-methoxy-phenyl)-propionic acid 2-bromo-ethyl ester 

Downstream Products

• 182249-67-8 (S)-2-Benzyloxycarbonylamino-3-(3-{4-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-2-methoxycarbonyl-ethyl]-phenoxy}-4-methoxy-phenyl)-propionic acid 
• 127559-24-4 Methyl (9S,12S,15S)-12-(2-amino-2-oxoethyl)-9-<<(phenylmethoxy)carbonyl>amino>-4-methoxy-10,13-dioxo-2-oxa-11,14-diazatricyclo<15.2.2.1^3,7>docosa-3,5,7(22),17,19,20-hexaene-15-carboxylate 

Relevant articles and documents

Application of arene-ruthenium chemistry to a formal total synthesis of OF 4949 III

A convergent formal total synthesis of OF 4949 III is described. Arene-ruthenium chemistry was used in the construction of the diaryl ether linkage in high yield, and cycloamidation under high dilution conditions (0.005 M) was achieved using DPPA as coupling reagent. SmI2 was used to reductively remove the 2-iodoethyl ester protecting group in the presence of DMPU or HMPA.