1823-62-7

Basic information

• Product Name: 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE
• Synonyms: [2-(4-BROMO-PHENOXY)-ETHYL]-DIETHYL-AMINE;4-(2-DIETHYLAMINO)ETHOXY-BROMOBENZENE;4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE;4-(2-N,N-DIETHYLAMINOETHOXY)BROMOBENZENE;Ethanamine, 2-(4-bromophenoxy)-N,N-diethyl-
• CAS NO: 1823-62-7
• Molecular Formula: C₁₂H₁₈BrNO
• Molecular Weight: 272.18
• Mol File: 1823-62-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 319.5 °C at 760 mmHg
• Flash Point: 147 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 0.000338mmHg at 25°C
• Refractive Index: 1.527
• PKA: 9.54±0.25(Predicted)
• CAS DataBase Reference: 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE(1823-62-7)
• EPA Substance Registry System: 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE(1823-62-7)

Safety Data

• Hazardous Substances Data: 1823-62-7(Hazardous Substances Data)

Usage

General Description

4-[2-N,N-Diethylethoxy]phenyl bromide is a chemical compound that belongs to the class of phenyl bromides. It is a derivative of phenyl bromide, with the addition of a diethylethoxy group at the 2-position of the phenyl ring. 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE is commonly used in organic synthesis and is a valuable building block for the preparation of various pharmaceuticals, agrochemicals, and materials. It has the potential for use as a substrate for the synthesis of novel compounds with potential biological activity. Additionally, it is important to handle and use this compound with caution, as it is a halogenated organic compound and may have hazardous effects if not properly managed and controlled.

InChI:InChI=1/C12H18BrNO/c1-3-14(4-2)9-10-15-12-7-5-11(13)6-8-12/h5-8H,3-4,9-10H2,1-2H3

Upstream product

• 106-41-2 4-bromo-phenol 
• 100-35-6 2-(diethylamino)ethyl chloride 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 7003-65-8 sodium 4-bromophenoxide 
• 67-56-1 methanol 

Downstream Products

• 3704-91-4 1-[4-(2-Diethylamino-ethoxy)-phenyl]-1-(3,4,5-trimethoxy-phenyl)-ethylen 
• 3950-35-4 (Biphenyl-4-yl)-<4-(2-diethylamino-ethoxy)-phenyl>-phenylmethanol 
• 3704-70-9 <4-(2-Diaethylamino-aethoxy)-phenyl>-phenyl-<4-trifluormethyl-phenyl>-methanol 
• 749-86-0 {2-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenoxy]-ethyl}-diethyl-amine 
• 3704-74-3 (4-Chlor-phenyl)-cyclopropyl-[4-(2-diethylamino-ethoxy)-phenyl]-methanol 
• 3704-75-4 [4-(2-Diaethylamino-aethoxy)-phenyl]-(4-methyl-phenyl)-phenaethyl-methanol 
• 2041-71-6 Diethyl-{2-[4-((E)-1,2,3-triphenyl-propenyl)-phenoxy]-ethyl}-amine 
• 2239-35-2 {2-[4-((Z)-1,2-Diphenyl-penta-1,4-dienyl)-phenoxy]-ethyl}-diethyl-amine 
• 2041-70-5 Diethyl-{2-[4-((E)-2-phenyl-1-p-tolyl-propenyl)-phenoxy]-ethyl}-amine 
• 2041-72-7 {2-[4-((Z)-1,2-Diphenyl-pent-1-enyl)-phenoxy]-ethyl}-diethyl-amine 
• 2220-38-4 (Acenaphthen-5-yl)-<4-(2-diethylamino-ethoxy)-phenyl>-phenyl-methanol 
• 3704-71-0 <4-(2-Diethylamino-ethoxy)-phenyl>--methanol 
• 2041-73-8 Diethyl-(2-{4-[(E)-1-(4-methoxy-phenyl)-2,3-diphenyl-propenyl]-phenoxy}-ethyl)-amine 
• 2236-17-1 2-(4-Chloro-phenyl)-1-[4-(2-diethylamino-ethoxy)-phenyl]-1-phenyl-propan-1-ol 

Relevant articles and documents

Industrial synthesis of 4-chloro, 11β-arylestradiol: How to circumvent a poor diastereoselectivity

An industrial synthesis of 11β-arylestrone derivatives is described, based on the conjugate opening of a mixture of allylic 5(10)-α and -β epoxides by an aryl cuprate generated catalytically, followed by hydrolysis and subsequent aromatisation of the isomeric mixture of arylation products. An original method for selective 4-chlorination of estrone derivatives is also described.

Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

The present invention relates to alkyne compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one alkyne according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

Sila-Pharmaca, 34th communication [1]. Sila-analogues of triparanol and ethamoxytriphetol: Synthesis as well as pharmacological and toxicological properties

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