18232-91-2

Basic information

• Product Name: 3-PICOLINE, 4,5-DIAMINO-6-CHLORO-
• Synonyms: 3-PICOLINE, 4,5-DIAMINO-6-CHLORO-;2-Chloro-3,4-diamino-5-methylpyridine;2-Chloro-5-Methylpyridine-3,4-diaMine
• CAS NO: 18232-91-2
• Molecular Formula: C₆H₈ClN₃
• Molecular Weight: 157.6
• Mol File: 18232-91-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-PICOLINE, 4,5-DIAMINO-6-CHLORO-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PICOLINE, 4,5-DIAMINO-6-CHLORO-(18232-91-2)
• EPA Substance Registry System: 3-PICOLINE, 4,5-DIAMINO-6-CHLORO-(18232-91-2)

Safety Data

• Hazardous Substances Data: 18232-91-2(Hazardous Substances Data)

Usage

General Description

3-PICOLINE, 4,5-DIAMINO-6-CHLORO- is a chemical compound that consists of a 3-picolylamine moiety, a 4,5-diamino-6-chloropyrimidine moiety and covalently bonded with a hydrogen atom. It is used in various fields such as pharmaceuticals, agrochemicals, and dyestuffs as an intermediate or raw material. This chemical compound can be used to synthesize various pharmaceutical products and can also act as a building block for the preparation of other chemical compounds. It has potential applications in the development of new drugs and has properties that make it a valuable component in the construction of different chemical structures.

Upstream product

• 18227-66-2 4-nitramino-3-methylpyridine 
• 1990-90-5 4-amino-3-methylpyridine 
• 1003-73-2 3-picoline-N-oxide 
• 1074-98-2 3-methyl-4-nitropyridine N-oxide 
• 18227-67-3 4-amino-3-methyl-5-nitropyridine 

Downstream Products

• 1421597-90-1 C₃₃H₂₈N₈O 
• 1421597-89-8 C₃₃H₃₁N₇O 
• 515815-10-8 2'-deoxy-3',5'-di-O-p-toluoyl-4-chloro-7-methyl-1-β-D-ribofuranosyl-1(H)-imidazo[4,5-c]pyridine 
• 515815-09-5 2'-deoxy-3',5'-di-O-p-toluoyl-7-chloro-4-methyl-1-β-D-ribofuranosyl-3(H)-imidazo[4,5-c]pyridine 

Relevant articles and documents

The synthesis of anti-fixed 3-methyl-3-deaza-2′-deoxyadenosine and other 3h-imidazo[4,5-c]pyridine analogs

Rotation of a heterocyclic base around a glycosidic bond allows the formation of syn and anti conformations in nucleosides. The syn conformation has been observed primarily in purine-purine mismatches in DNA duplexes. Such mismatches give rise to false positive oligonucleotide hybridization in DNA-based diagnostics. Here we describe the synthesis of an analog of 2′-deoxyadenosine that retains its Watson-Crick functional groups, but cannot form the syn conformation. In this analog, the N3 atom of 2′-deoxyadenosine is replaced by a C-CH3 group to give 7-methyl-1-β-D-deoxyribofuranosyl-1H-imidazo[4,5-c]pyridin-4-ylamine or 3-methyl-3-deaza-2′-deoxyadenosine (3mddA). This modification sterically prevents the syn conformation and 3mddA becomes an anti-fixed nucleoside analog of 2′-deoxyadenosine. The synthesis and conformational analysis of 3mddA and several analogs with an 3H-imidazo[4,5-c]pyridine skeleton are described, as well as their potential applications.