182344-18-9

Basic information

• Product Name: 2-Chloro-5-(trifluoromethyl)phenylboronic acid
• Synonyms: 2-CHLORO-5-(TRIFLUOROMETHYL)BENZENEBORONIC ACID;2-CHLORO-5-(TRIFLUOROMETHYL)PHENYLBORONIC ACID;AKOS BRN-0226;2-CHLORO-5-(TRIFLUOROMETHYL)PHENYLBORON&;2-Chloro-5-(Trifluoromethyl)Ph;2-chloro-5-trifluoromethphenylboronic acid;2-Chloro-5-(trifluoroMethyl)phenylboronic Acid (contains varying aMounts of Anhydride);2-Chloro-5-(trifluoroMethyl)benzeneboronic acid (contains varying aMounts of anhydride)
• CAS NO: 182344-18-9
• Molecular Formula: C7H5BClF3O2
• Molecular Weight: 224.37
• Product Categories: blocks;BoronicAcids;Boronic Acid;Aryl;Fluorinated;Organoborons;Boronic Acids;Boronic Acids and Derivatives;Aryl Boronic Acids;Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Disubstituted Aryl Boronic Acids;Organometallic Reagents;Boronate Ester;Potassium Trifluoroborate
• Mol File: 182344-18-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 108 °C
• Boiling Point: 303.2 °C at 760 mmHg
• Flash Point: 137.2 °C
• Appearance: off-white crystal
• Density: 1.49 g/cm³
• Vapor Pressure: 0.000415mmHg at 25°C
• Refractive Index: 1.484
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Methanol
• PKA: 7.26±0.58(Predicted)
• CAS DataBase Reference: 2-Chloro-5-(trifluoromethyl)phenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-(trifluoromethyl)phenylboronic acid(182344-18-9)
• EPA Substance Registry System: 2-Chloro-5-(trifluoromethyl)phenylboronic acid(182344-18-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: UN 3335
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 182344-18-9(Hazardous Substances Data)

Usage

Description

2-Chloro-5-(trifluoromethyl)phenylboronic acid is an organic compound that belongs to the class of phenylboronic acids. It is characterized by the presence of a chlorine atom at the 2nd position and a trifluoromethyl group at the 5th position on a phenyl ring, with a boronic acid group attached to the ring. 2-Chloro-5-(trifluoromethyl)phenylboronic acid exhibits off-white crystalline properties and is commonly utilized in various chemical reactions and applications due to its unique structural features.

Uses

Used in Pharmaceutical Industry:
2-Chloro-5-(trifluoromethyl)phenylboronic acid is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential applications in treating different medical conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Chloro-5-(trifluoromethyl)phenylboronic acid serves as a key building block for the creation of a wide range of organic molecules. Its reactivity and structural properties make it a valuable component in the synthesis of complex organic compounds.
Used in Suzuki Reaction:
2-Chloro-5-(trifluoromethyl)phenylboronic acid is used as a reagent in the Suzuki reaction, a widely employed method for the formation of carbon-carbon bonds. This reaction is particularly useful in the synthesis of biologically active molecules and materials with potential applications in various industries.
Used in Material Science:
The compound is also utilized in the development of new materials with specific properties, such as improved thermal stability, chemical resistance, or electrical conductivity. Its unique structure and reactivity contribute to the creation of advanced materials for various applications.

InChI:InChI=1/C7H5BClF3O2/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,13-14H

Downstream Products

• 909849-12-3 3-{6-[2-chloro-5-(trifluoromethyl)phenyl]-3-pyridinyl}-2,6-dimethyl-4H-pyran-4-one 
• 1431162-98-9 1-phenyl-6-(trifluoromethyl)-3,4-dihydroquinolin-2(1H)-one