182370-37-2

Basic information

• Product Name: Thiophosphorofluoridic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester
• Synonyms: Thiophosphorofluoridic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester
• CAS NO: 182370-37-2
• Molecular Weight: 642.642
• Mol File: 182370-37-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Thiophosphorofluoridic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophosphorofluoridic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester(182370-37-2)
• EPA Substance Registry System: Thiophosphorofluoridic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester(182370-37-2)

Safety Data

• Hazardous Substances Data: 182370-37-2(Hazardous Substances Data)

Upstream product

• 179090-12-1 5'-O-DMT-thymidine 3'-O-(2-thio-1,3,2-oxathiaphospholane) 
• 171081-13-3 Phosphorofluoridous acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 171081-12-2 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 171081-10-0 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) phosphorofluoridite 
• 162611-40-7 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite 
• 153413-66-2 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(4-nitrophenyl) N,N-diisopropylphosphoramidite 
• 171081-20-2 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) thiophosphorofluoridate 
• 171081-18-8 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate 
• 162611-38-3 O-(5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-2-deoxyadenosin-3'-yl) N,N-diisopropylfluorophosphoramidite 

Relevant articles and documents

Synthesis and chemical and enzymatic reactivity of thymidine 3′-O- and 5′-O-phosphorofluoridothioates

5′-O- or 3′-O-Protected thymidine 3′-O- or 5′-O-(2-thiono-1,3,2-oxathiaphospholanes) react with triethylammonium fluoride in a presence of DBU and furnish, after deprotection, thymidine 3′-O- and 5′-O-phosphorofluoridothioates; the latter undergoes stereo

Novel phosphitylating reagents containing a phosphorus-fluorine bond and their application in efficient synthesis of phosphorofluoridates and phosphorofluoridothionates

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