18243-97-5Relevant articles and documents
Synthesis of L-ascorbic acid derivatives as potential bone remodeling agents taking advantage of the Mitsunobu reaction
Vila?a, Gil,Rubio, Cyril,Susperregui, Jacques,Latxague, Laurent,Déléris, Gérard
, p. 9249 - 9256 (2007/10/03)
The synthesis of ascorbic acid derivatives 7a-d is described. Starting from alkenylacetates 1a-d subjected to a hydrosilylation reaction, the resulting hydroxy chloro silanes 3a-d were obtained in high yield. The latter compounds were reacted with potassium phthalimide followed with hydrazine hydrate to give the amino silanols 5a-d. Ascorbic acid was then alkylated on its 3-hydroxy position to give 7a-d by means of a Mitsunobu reaction.
