18247-78-4

Basic information

• Product Name: Propanehydrazonoyl chloride, N-(4-chlorophenyl)-2-oxo-
• CAS NO: 18247-78-4
• Molecular Formula: C9H8Cl2N2O
• Molecular Weight: 231.081
• Mol File: 18247-78-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Propanehydrazonoyl chloride, N-(4-chlorophenyl)-2-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanehydrazonoyl chloride, N-(4-chlorophenyl)-2-oxo-(18247-78-4)
• EPA Substance Registry System: Propanehydrazonoyl chloride, N-(4-chlorophenyl)-2-oxo-(18247-78-4)

Safety Data

• Hazardous Substances Data: 18247-78-4(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 1694-29-7 3-chloropentane-2,4-dione 
• 2028-74-2 p-chlorobenzenediazonium chloride 

Downstream Products

• 153937-37-2 3-acetyl-5-amino-1-p-chlorophenylpyrazole-4-carboxamide 
• 1086820-99-6 4-acetyl-2-(4-chlorophenyl)pyrimido[2,1-d]-1,2,3,5-tetrazine 
• 1030624-60-2 3-methyl-7-phenyl-2H-imidazo[2,1-b][1,3,4]thiadiazin-2-one 2-(4-chlorophenyl)hydrazone 
• 1079363-94-2 C₁₈H₁₅ClN₄O 

Relevant articles and documents

Synthesis and cytotoxic activity study of novel 2-(Aryldiazenyl)-3-methyl-1h-benzo[g]indole derivatives

A novel series of 2-(aryldiazenyl)-3-methyl-1H-benzo[g]indole derivatives (3a–f) were prepared through the cyclization of the corresponding arylamidrazones, employing polyphosphoric acid (PPA) as a cyclizing agent. All of the compounds (3a–f) were characterized using1H NMR,13C NMR, MS, elemental analysis, and melting point techniques. The synthesized compounds were evaluated for cytotoxic activity against diverse human cancer cell lines by the National Cancer Institute. While all of the screened compounds were found to be cytotoxic at a 10 μM concentration, two of them (2c) and (3c) were subjected to five dose screens and showed a significant cytotoxicity and selectivity.

Synthesis and structure-activity relationship; exploration of some potent anti-cancer phenyl amidrazone derivatives

Background: Amidrazones have been reported to have significant anti-tumor properties against several cancer cell lines. Objectives: The current project aims to profile the structure-anticancer activity relationship of phenyl-amidrazons. Methods: Fifteen p

Synthesis, in vitro and in Silico studies of some novel 5-nitrofuran-2-yl hydrazones as antimicrobial and antitubercular agents

In this study, we synthesized two series of novel 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e in addition to a third series of thiophene-2-carbohydrazides 23a-g to develop potent antimicrobial and/or antitubercular agents. The newly synthesized compounds were evaluated in vitro for their antimicrobial and antimycobacterial activities. Most of the 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e displayed variable activity against Aspergillus fumigates, Staphylococcus aureus, Streptococcus pneumonia, Bacillis subtilis, Salmonella typhimurium, Klebsiella pneumonia, Escherichia coli and Mycobacterium tuberculosis. The sulfonamide derivative 21f exhibited superior potency and broad-spectrum antimicrobial activity with minimum inhibitory concentration (MIC)=0.06-0.98 μg/mL and antimycobacterial activity with MIC=3.9 μg/mL. The 5-nitrofuran-2-carbohydrazides 21a, b, g, h and 22a-c exhibited significant antibacterial activity with MIC values in the range of 0.12-7.81 μg/mL. The significances of the 5-nitrofuran moiety and sulfonamide function were explored via the structure-activity relationship (SAR) study. In addition, docking studies revealed that the p-amino benzoic acid (PABA) and binding pockets of the dihydropteroate synthase (DHPS) were successfully occupied by compound 21f. Furthermore, two quantitative structure-activity relationship (QSAR) models were built to explore the structural requirements which controlled the activity.