1825-67-8

Basic information

• Product Name: 2-(Trimethylsilyloxy)pentane
• Synonyms: (1-Methylbutoxy)trimethylsilane;2-(Trimethylsilyloxy)pentane;Trimethyl(1-methylbutoxy)silane
• CAS NO: 1825-67-8
• Molecular Formula: C₈H₂₀OSi
• Molecular Weight: 0
• Mol File: 1825-67-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(Trimethylsilyloxy)pentane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Trimethylsilyloxy)pentane(1825-67-8)
• EPA Substance Registry System: 2-(Trimethylsilyloxy)pentane(1825-67-8)

Safety Data

• Hazardous Substances Data: 1825-67-8(Hazardous Substances Data)

Usage

Organosilicon compound

Contains a silicon atom bonded to an organic group.

Use as an intermediate

Commonly used in the synthesis of other organic compounds.

Primary use

As a protecting group for alcohols, allowing selective reactions at other functional groups in the molecule.

Secondary use

Can be used as a solvent in various chemical reactions.

Value in the laboratory

Its chemical properties make it a valuable and versatile tool for chemists.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 6032-29-7 (+/-)-2-pentanol 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 

Downstream Products

• 6032-29-7 (+/-)-2-pentanol 

Relevant articles and documents

Synthetic Versatility of Lipases: Application for Si-O Bond Formation and Cleavage

Several commercially available lipases were examined in a study on O-Si bond formation and cleavage applying silicon-based protecting groups and alcohols or the corresponding silyl ethers. With regard to deprotection, from silyl ether to the corresponding alcohol, only the solvent and the lipase were necessary. The influence of the protecting group, the lipase source, and the substituent was investigated to optimize the results. The TMS moiety could be removed in 24 hours of reaction at room temperature in aqueous systems (conv. up to 99%, depending on the substrate and lipase). The reverse reactions, that is, with the protection of the alcohols, were carried out in hexane using different silyl chlorides. The TMS, TES, and TBS moieties were successfully inserted in the primary and secondary alcohols without the need for dry conditions or an inert atmosphere, presenting conversions of up to 99%, depending on the substrate.