182565-33-9

Basic information

• Product Name: 1-(4-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroquinoline
• Synonyms: 1-(4-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroquinoline
• CAS NO: 182565-33-9
• Molecular Weight: 318.353
• Mol File: 182565-33-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(4-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroquinoline(182565-33-9)
• EPA Substance Registry System: 1-(4-nitrobenzenesulfonyl)-1,2,3,4-tetrahydroquinoline(182565-33-9)

Safety Data

• Hazardous Substances Data: 182565-33-9(Hazardous Substances Data)

Upstream product

• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 182565-31-7 N-p-nitrobenzenesulfonyl-3-phenylpropylamine 

Downstream Products

• 635-46-1 1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

A mild copper-mediated intramolecular amination of aryl halides

A unique combination of copper iodide and cesium acetate was found to mediate intramolecular amination of aryl halides under mild conditions. The reaction proceeds at room temperature with primary or N-benzyl amines and at moderately elevated temperatures with other amine derivatives. The reaction has been applied to the formation of 5-, 6-, and 7-membered rings. Remarkably, halogens at the meta-position were retained, providing a definitive advantage over palladium-catalyzed systems.

Cyclic amination onto aromatic ring of sulfonamides with (diacetoxyiodo)arenes: Effect of sulfonyl group

Sulfonamides of primary amine bearing an aromatic ring at γ-position were treated with (diacetoxyiodo)arene and iodine under irradiation conditions with a tungsten lamp to give the corresponding 1,2,3,4-tetrahydroquinoline derivatives in moderate to good

Aromatic sulfonamides containing a condensed piperidine moiety as potential oxidative stress-inducing anticancer agents

A 30-membered piperidine ring-fused aromatic sulfonamide library was synthetized, including N-arylsulfonyl 1,2,3,4-tetrahydroquinolines, 1,2,3,4-tetrahydroisoquinolines and 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indoles. The compounds induced oxidative stress

Study on Radical Amidation onto Aromatic Rings with (Diacyloxyiodo)arenes

Sulfonamides of primary amines bearing an aromatic ring at the γ-position were treated with (diacyloxyiodo)arenes and iodine under irradiation conditions with a tungsten lamp to give the corresponding 1,2,3,4-tetrahydroquinoline derivatives in moderate to good yields. Here, the reactivity depends on the Z-group (protecting group) of the starting amides. Under the same reaction conditions, some sulfonamides were treated with (diacetoxyiodo)benzene and iodine in the presence of aromatics to give the corresponding N-arylated amides. These reactions proceed through the intramolecular and intermolecular amidations onto aromatic rings via the sulfonamidyl radicals formed.