1826-56-8

Basic information

• Product Name: N-ETHYL-4'-NITROACETANILIDE
• Synonyms: N-ETHYL-4'-NITROACETANILIDE;p-Nitro-N-ethylacetanilide;N-ethyl-N-(4-nitrophenyl)acetamide
• CAS NO: 1826-56-8
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.21
• Mol File: 1826-56-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 353.8°Cat760mmHg
• Flash Point: 167.8°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 3.49E-05mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: N-ETHYL-4'-NITROACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ETHYL-4'-NITROACETANILIDE(1826-56-8)
• EPA Substance Registry System: N-ETHYL-4'-NITROACETANILIDE(1826-56-8)

Safety Data

• Hazardous Substances Data: 1826-56-8(Hazardous Substances Data)

Usage

General Description

N-ETHYL-4'-NITROACETANILIDE is a chemical compound that is commonly used as an intermediate in the production of various pharmaceuticals and organic materials. It is synthesized by reacting 4-nitroacetanilide with ethyl iodide in the presence of a strong base. N-ETHYL-4'-NITROACETANILIDE is a nitro derivative of acetanilide, which is a known analgesic and antipyretic drug. N-ETHYL-4'-NITROACETANILIDE has potential applications in the development of new drugs and in the synthesis of other organic chemicals. It is important to handle this substance with care, as it is considered hazardous and may pose health risks if not handled properly.

InChI:InChI=1/C10H12N2O3/c1-3-11(8(2)13)9-4-6-10(7-5-9)12(14)15/h4-7H,3H2,1-2H3

Upstream product

• 529-65-7 N-ethylacetanilide 
• 3665-80-3 N-Ethyl-4-nitroanilin 
• 108-24-7 acetic anhydride 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 75-03-6 ethyl iodide 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 75-36-5 acetyl chloride 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 3665-80-3 N-Ethyl-4-nitroanilin 
• 5840-09-5 4-amino-1-(N-ethylamino)benzene 
• 2051-82-3 acetic acid-(N-ethyl-4-amino-anilide) 

Relevant articles and documents

A Facile Oxidation of Tertiary Amines to Lactams by Using Sodium Chlorite: Process Improvement by Precise pH Adjustment with CO 2

By using cheap and innocuous sodium chlorite, a series of tertiary amines have been oxidized to the corresponding lactams with good selectivity and high yield. In this method, neither transition-metal catalyst nor oxidant was used. In the oxidation step, the pH of the sodium chlorite was precisely adjusted to pH around 6 using CO2, such pH is a compromise between oxidative properties, chemical stability, and unwanted precipitation. In addition, buffer salts are not necessary, which allows this oxidation reaction to be performed under safe and environmentally benign conditions.

Purine derivatives inhibitors of tyrosine protein kinase SYK

Disclosed are compounds of the formula in free or salt form, wherein X, R1, R2, R3, and R4are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment o