182621-75-6

Basic information

• Product Name: (R)?2?bromo?1?(4′?chlorophenyl)ethanol
• Synonyms: (R)?2?bromo?1?(4′?chlorophenyl)ethanol
• CAS NO: 182621-75-6
• Molecular Weight: 235.508
• Mol File: 182621-75-6.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: (R)?2?bromo?1?(4′?chlorophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)?2?bromo?1?(4′?chlorophenyl)ethanol(182621-75-6)
• EPA Substance Registry System: (R)?2?bromo?1?(4′?chlorophenyl)ethanol(182621-75-6)

Safety Data

• Hazardous Substances Data: 182621-75-6(Hazardous Substances Data)

Upstream product

• 37577-28-9 (1S,2R)-(+)-norphedrine 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 6314-52-9 2-bromo-1-(4-chlorophenyl)ethanol 
• 22651-87-2 cyclohexanecarboxylic acid anhydride 
• 1875-88-3 2-(4-Chlorophenyl)ethanol 
• 6529-53-9 1-(2-bromoethyl)-4-chlorobenzene 
• 108-05-4 vinyl acetate 
• 1073-67-2 4-vinylbenzyl chloride 
• 33491-03-1 1-(bromoethynyl)-4-chlorobenzene 

Downstream Products

• 6314-62-1 C₁₅H₁₆ClNO 
• 2788-86-5 (R)-2-(4-chlorophenyl)oxirane 

Relevant articles and documents

Chiral guanidine catalyzed acylative kinetic resolution of racemic 2-bromo-1-arylethanols

In this study, chiral guanidine catalyzed acylative kinetic resolution of racemic 2-bromo-1-arylethanols was achieved with high selectivity. Irrespective of the electronic nature and the substitution patterns on the aromatic rings, a variety of substrates were suitable for this reaction. The branched acyl component was considered to be optimal for obtaining high s-values. The transition state of the reaction was proposed based on the absolute configuration of the obtained product.

Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons

A stereoselective hydroxylation and enantioselective dehalogenation cascade reaction was developed for the synthesis of optically active β-haloalcohols from halohydrocarbons. This cascade system employed P450 and halohydrin dehalogenase as two compatible biocatalysts, allowing a straightforward, greener and efficient access to β-halohydrins with excellent enantioselectivities (98-99%).

Immobilization of Amano lipase from Pseudomonas fluorescens on silk fibroin spheres: an alternative protocol for the enantioselective synthesis of halohydrins

The search for a new, efficient, cheaper and sustainable matrix for lipase immobilization is a growing area in biotechnology. Amano lipase from Pseudomonas fluorescens was immobilized on silk fibroin spheres and used in the enzymatic kinetic resolution of halohydrins, to obtain optically active epoxides (up to 99% ee), important precursors in the synthesis of derivative antifungal azoles. This paper reinforces the versatility of silk fibroin as a support for heterogeneous catalysts.