182691-67-4

Basic information

• Product Name: Furo[3,2-b]pyridine-5-carbonitrile(9CI)
• Synonyms: Furo[3,2-b]pyridine-5-carbonitrile(9CI);furo[3,2-b]pyridine-5-carbonitrile
• CAS NO: 182691-67-4
• Molecular Formula: C₈H₄N₂O
• Molecular Weight: 144.13
• Product Categories: PYRIDINE
• Mol File: 182691-67-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Furo[3,2-b]pyridine-5-carbonitrile(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[3,2-b]pyridine-5-carbonitrile(9CI)(182691-67-4)
• EPA Substance Registry System: Furo[3,2-b]pyridine-5-carbonitrile(9CI)(182691-67-4)

Safety Data

• Hazardous Substances Data: 182691-67-4(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 181526-18-1 4-oxidofuro[3,2-b]pyridin-4-ium 
• 151-50-8 potassium cyanide 
• 272-62-8 furo[3,2-b]pyridine 

Downstream Products

• 56473-91-7 furo<3,2-b>pyridine-5-carboxylic acid 
• 193750-69-5 5-acetylfuro[2,3-b]pyridine 

Relevant articles and documents

GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7- nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Furopyridines. XVII [1]. Cyanation, chlorination and nitration of furo[3,2-b]pyridine N-oxide

The N-oxide 2 of furo[3,2-b]pyridine (1) was cyanated by the Reissert-Henze reaction with potassium cyanide and benzoyl chloride to give 5-cyano derivative 3, which was converted to the carboxamide 4, carboxylic acid 5, ethyl ester 6 and ethyl imidate 8. Chlorination of 2 with phosphorus oxychloride yielded 2-9a, 3- 9b, 5- 9c and 7-chloro derivative 9d. Reaction of 9d with sodium methoxide, pyrrolidine, N,N-dimethylformamide and ethyl cyanoacetate afforded 7-methoxy- 10, 7-(1-pyrrolidyl)- 11 and 7-dimethylaminofuro[3,2-b]pyridine (14) and 7-(1-cyano-1-ethoxy-carbonyl)methylene-4,7-dihydro-furo[3,2-b]pyridine (12). Nitration of 2 with a mixture of fuming nitric acid and sulfuric acid gave 2-nitrofuro[3,2-b]pyridine N-oxide (15).