182753-55-5

Basic information

• Product Name: 1-Acetyl-3-[1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
• Synonyms: 1-Acetyl-3-[1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
• CAS NO: 182753-55-5
• Molecular Weight: 279.295
• Mol File: 182753-55-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Acetyl-3-[1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acetyl-3-[1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one(182753-55-5)
• EPA Substance Registry System: 1-Acetyl-3-[1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one(182753-55-5)

Safety Data

• Hazardous Substances Data: 182753-55-5(Hazardous Substances Data)

Upstream product

• 21905-78-2 N-acetyloxindole 
• 90-02-8 salicylaldehyde 
• 182753-51-1 1-Acetyl-3-[1-[2-(3-methyl-but-2-enyloxy)-phenyl]-meth-(E)-ylidene]-1,3-dihydro-indol-2-one 
• 56074-73-8 2-(3-methyl-2-butenyloxy)benzaldehyde 

Relevant articles and documents

Phosphine-Mediated Rauhut-Currier-Type/Acyl Transfer/ Wittig Strategy for Synthesis of Spirocyclopenta[c]chromene-Indolinones

A phosphine-mediated reaction for the construction of spirocyclopenta[c]chromene-indolinones is reported via a Rauhut-Currier (RC)-type/acyl transfer/Wittig sequence. This methodology attributes the chemoselective phosphine addition to the alkynoate which generates the phosphorus zwitterion via RC-type reaction, and that further undergoes O-acylation to form the seven-membered betaine intermediate with acyl chloride in the presence of base. Extensive investigations reveal that the exceptional δ-acylation occurs through the C?O bond cleavage upon the seven-membered betaine, and the subsequent Wittig reaction preferentially result in the aforementioned spiro compounds. Furthermore, our protocol could also be applicable to different alkynoates to provide a series of spirocyclopenta[c]chromenones bearing privileged skeletons. (Figure presented.).