18276-81-8

Basic information

• Product Name: Phosphonic acid, [2-(4-methylphenyl)-2-oxoethyl]-, diethyl ester
• CAS NO: 18276-81-8
• Molecular Formula: C13H19O4P
• Molecular Weight: 270.265
• Mol File: 18276-81-8.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [2-(4-methylphenyl)-2-oxoethyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [2-(4-methylphenyl)-2-oxoethyl]-, diethyl ester(18276-81-8)
• EPA Substance Registry System: Phosphonic acid, [2-(4-methylphenyl)-2-oxoethyl]-, diethyl ester(18276-81-8)

Safety Data

• Hazardous Substances Data: 18276-81-8(Hazardous Substances Data)

Upstream product

• 3095-95-2 diethylphosphonoacetic acid 
• 874-60-2 4-methyl-benzoyl chloride 
• 356102-22-2 4'-methylacetophenone carbomethoxyhydrazone 
• 122-52-1 triethyl phosphite 
• 20511-20-0 ethyl p-methylcinnamate 
• 762-04-9 phosphonic acid diethyl ester 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 
• 13565-38-3 3-(4-fluorophenyl)-1-p-tolylprop-2-en-1-one 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 
• 766-97-2 4-n-methylphenylacetylene 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 18103-98-5 3-dimethylamino-1-(4-methyl-phenyl)-2-propen-1-one 
• 4023-79-4 1-(4-methylphenyl)butan-1,3-dione 
• 89108-49-6 1-(1-azidovinyl)-4-methyl benzene 

Downstream Products

• 82102-03-2 diethyl 2-amino-2-(4-tolyl)ethylphosphonate 
• 1416178-19-2 C₁₅H₂₂N₃O₄P 
• 1451191-65-3 C₁₆H₂₄NO₃P 
• 1451191-86-8 C₁₆H₂₄NO₃P 
• 1451191-87-9 C₁₆H₂₄NO₃P 
• 64214-93-3 5-p-tolyl-1-(3-trifluoromethyl-phenyl)-1H-[1,2,3]triazole 
• 169590-42-5 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide 
• 1213781-22-6 C₁₆H₁₈O₂ 
• 82102-17-8 2-(4-methylphenyl)-2-aminoethylphosphonic acid 
• 173847-67-1 diethyl 2-(p-methylphenyl)-2-hydrazonoethylphosphonate 
• 23755-77-3 Diethyl α-brom-p-methylphenacylphosphonat 
• 39022-93-0 C₃₀H₂₆O₂ 

Relevant articles and documents

Solid phase acylation of phosphonoacetates: Synthesis of β-keto phosphonates from polymer bound phosphonoacetate

Solid phase synthesis of phase synthesis of β-keto phosphonates, via acylation reaction of polymer bound phosphoacetate with carboxylic acid chlorides in the presence of magnesium chloride-triethylamine followed by cleavage of resin with concomitant decarboxylation, is described.

Bivalent copper complex containing diphosphine ortho-position carborane ligand, preparation method and application thereof

The invention relates to a bivalent copper complex containing a diphosphine ortho-position carborane ligand, a preparation method and application thereof. The copper complex is prepared by the following method of: adding an n-BuLi solution dropwise into an ortho-position carborane o-C2B10H12 solution, and carrying out stirring reaction, then adding halogenated phosphine for continuous reaction, adding copper acetate Cu(OAc)2 into the reaction system for continuous reaction, after the reaction is finished, performing separating to obtain the diphosphine ortho-position carborane ligand, and applying the copper complex to catalytic synthesis of a beta-carbonyl phosphine oxide compound. Compared with the prior art, the synthesis process has excellent selectivity and high yield, the copper complex can catalyze alpha-haloketone and phosphite to react to synthesize the beta-carbonyl phosphine oxide compound under the room temperature condition, and the reaction is efficient, green and environmentally friendly.

Mukaiyama reagent-promoted metal-free preparation of alkynyl sulfones and phosphonates under mild conditions

An efficient and mild route for the formation sulfur or phosphor-substituted alkynes was herein demonstrated. The Mukaiyama reagent-mediated transformation started from easily-accessible substrates without carbon-carbon triple bonds, and the reaction proceeded under mild conditions (room temperature) in a one-pot manner, requiring for no transition metal-catalysts. The practical protocol featured for good functional groups tolerance (up to 41 examples) and high efficiency (up to 91% yields) towards alkynyl sulfones and alkynyl phosphonates at low cost.