182760-73-2

Basic information

• Product Name: 1,14-Diazido-3,6,9,12-tetraoxatetradecane
• Synonyms: 1,14-Diazido-3,6,9,12-tetraoxatetradecane;Azido-dPEG4-Azido;N3-PEG4-N3
• CAS NO: 182760-73-2
• Molecular Formula: C₁₀H₂₀N₆O₄
• Molecular Weight: 0
• Product Categories: All Aliphatics;Aliphatics;Cross Linking Reagents;Aliphatics, Cross Linking Reagents
• Mol File: 182760-73-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Density: 1.129
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform
• CAS DataBase Reference: 1,14-Diazido-3,6,9,12-tetraoxatetradecane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,14-Diazido-3,6,9,12-tetraoxatetradecane(182760-73-2)
• EPA Substance Registry System: 1,14-Diazido-3,6,9,12-tetraoxatetradecane(182760-73-2)

Safety Data

• Hazardous Substances Data: 182760-73-2(Hazardous Substances Data)

Usage

Description

1,14-diazido-3,6,9,12-tetraoxatetradecane is a multifunctional alkylating agent characterized by its clear, colorless oil appearance. It is a chemical compound with potential applications in various industries due to its unique properties.

Uses

1,14-diazido-3,6,9,12-tetraoxatetradecane is used as a multifunctional alkylating agent for its ability to form covalent bonds with various molecules, making it a versatile compound in chemical reactions and synthesis processes.
Used in Pharmaceutical Industry:
1,14-diazido-3,6,9,12-tetraoxatetradecane is used as a key component in the synthesis of pharmaceutical compounds, particularly those with alkylating properties. Its ability to form covalent bonds with other molecules allows for the creation of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 1,14-diazido-3,6,9,12-tetraoxatetradecane is used as a reagent to facilitate the formation of covalent bonds between molecules. This property makes it a valuable tool in the development of new chemical compounds and materials.
Used in Research and Development:
1,14-diazido-3,6,9,12-tetraoxatetradecane is also utilized in research and development settings, where its alkylating properties can be explored for potential applications in various scientific fields. Its clear, colorless oil appearance makes it easy to handle and incorporate into experimental procedures.
Overall, 1,14-diazido-3,6,9,12-tetraoxatetradecane is a versatile compound with a range of applications in different industries, primarily due to its unique alkylating properties and clear, colorless oil appearance.

InChI:InChI=1/C10H20N6O4/c11-15-13-1-3-17-5-7-19-9-10-20-8-6-18-4-2-14-16-12/h1-10H2

Upstream product

• 5197-65-9 1,14-dichloro-3,6,9,12-tetraoxatetradecane 
• 41024-91-3 penta(ethylene glycol) bis(p-toluenesulfonate) 
• 4792-15-8 Pentaethylene glycol 
• 109789-39-1 pentaethylene glycol dimesylate 
• 236754-49-7 14-azido-3,6,9,12-tetraoxatetradecyl 4-methylbenzenesulfonate 

Downstream Products

• 1204387-22-3 C₄₆H₅₄N₈O₇ 
• 1204387-17-6 C₄₆H₅₄N₈O₇ 
• 1622914-00-4 bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate 
• 68960-97-4 1,14-diamino-3,6,9,12-tetraoxatetradecane 

Relevant articles and documents

Catalytic Synthesis of PEGylated EGCG Conjugates that Disaggregate Alzheimer's Tau

The naturally occurring flavonoid ( )-epigallocatechin gallate (EGCG) is a potent disaggregant of tau fibrils. Guided by the recent cryo-electron microscopy (cryoEM) structure of EGCG bound to fibrils of tau derived from an Alzheimer s brain donor, methods to site-specifically modify the EGCG D-ring with aminoPEGylated linkers are reported. The resultant molecules inhibit tau fibril seeding by Alzheimer s brain extracts. Formulations of aminoPEGylated EGCG conjugated to the (quasi)-brain-penetrant nanoparticle Ferumoxytol inhibit seeding by AD-tau with linker length affecting activity. The protecting groupfree catalytic cycloaddition of amino azides to mono-propargylated EGCG described here provides a blueprint for access to stable nanoparticulate forms of EGCG potentially useful as therapeutics to eliminate Alzheimer s-related tau tangles.

HETEROCYCLIC DERIVATIVES

Compounds of the formula (I): Q1-Q2-Q3, in which Q1, Q2 and Q3 have the meanings indicated in Claim 1, degrade target proteins, and can be employed, inter alia, for the treatment of diseases such as cancer, multiple sclerosis, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Cross-linked cyclic porphyrin derivative and method for preparing the same

The present invention relates to a cross-linked cyclic porphyrin derivative and to a manufacturing method thereof. By using the crosslinked cyclic porphyrin derivative, it is possible to measure a change in color selectively when cations and anions are present together, and thus the cations and the anions, preferably Li cations and halogen anions, can be selectively detected without any separate labels.COPYRIGHT KIPO 2018