18278-24-5Relevant articles and documents
Deracemization through photochemical E/Z isomerization of enamines
Huang, Mouxin,Luo, Sanzhong,Pan, Tianrun,Zhang, Long
, p. 869 - 874 (2022/03/07)
Catalytic deracemization of a-branched aldehydes is a direct strategy to construct enantiopure a-tertiary carbonyls, which are essential to pharmaceutical applications. Here, we report a photochemical E/Z isomerization strategy for the deracemization of a-branched aldehydes by using simple aminocatalysts and readily available photosensitizers. A variety of racemic a-branched aldehydes could be directly transformed into either enantiomer with high selectivity. Rapid photodynamic E/Z isomerization and highly stereospecific iminium/enamine tautomerization are two key factors that underlie the enantioenrichment. This study presents a distinctive photochemical E/Z isomerization strategy for externally tuning enamine catalysis.
Palladium/TY-Phos-Catalyzed Asymmetric Intermolecular α-Arylation of Aldehydes with Aryl Bromides
Li, Wenbo,Liu, Feng,Pan, Zhangjin,Wu, Hai-Hong,Zhang, Junliang,Zhu, Shuai
, p. 18542 - 18546 (2021/07/21)
Despite much progress has been made in the asymmetric α-arylation reactions of cyclic ketones, lactones and lactams, the enantioselective α-arylation of acyclic carbonyl compounds lagged much behind due to the in situ generated Z/E-enolate intermediates l
Cobalt-Catalyzed Diborylation of 1,1-disubstituted Vinylarenes: A Practical Route to Branched gem-Bis(boryl)alkanes
Teo, Wei Jie,Ge, Shaozhong
supporting information, p. 1654 - 1658 (2018/01/15)
We report the first catalytic diborylation of 1,1-disubstituted vinylarenes with pinacolborane using a cobalt catalyst generated from bench-stable Co(acac)2 and xantphos. A wide range of 1,1-disubstituted vinylarenes underwent this transformati