1829-82-9

Basic information

• Product Name: 4-amino-N-butylbenzenesulfonamide
• Synonyms: 4-amino-N-butylbenzenesulfonamide;benzenesulfonamide, 4-amino-N-butyl-;4-azanyl-N-butyl-benzenesulfonamide
• CAS NO: 1829-82-9
• Molecular Formula: C₁₀H₁₆N₂O₂S
• Molecular Weight: 228.32
• Mol File: 1829-82-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 388.8 °C at 760 mmHg
• Flash Point: 188.9 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 2.99E-06mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-amino-N-butylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-N-butylbenzenesulfonamide(1829-82-9)
• EPA Substance Registry System: 4-amino-N-butylbenzenesulfonamide(1829-82-9)

Safety Data

• Hazardous Substances Data: 1829-82-9(Hazardous Substances Data)

Usage

General Description

4-amino-N-butylbenzenesulfonamide is a chemical compound with the molecular formula C10H15N3O2S. Also known as sulfabenzamide, it is a sulfonamide antibiotic and an enzyme inhibitor that has been used in the treatment of bacterial infections. It functions by inhibiting the synthesis of dihydrofolic acid, a key component for the biosynthesis of nucleic acids in bacteria. This disruption ultimately leads to the suppression of bacterial growth and reproduction. It is primarily used in veterinary medicine for the treatment of bacterial infections in animals, particularly in poultry and swine. In addition to its antibiotic properties, 4-amino-N-butylbenzenesulfonamide also has anti-inflammatory effects and has been studied for potential therapeutic applications in neurological disorders.

InChI:InChI=1/C10H16N2O2S/c1-2-3-8-12-15(13,14)10-6-4-9(11)5-7-10/h4-7,12H,2-3,8,11H2,1H3

Upstream product

• 72225-61-7 N-acetyl-sulfanilic acid butylamide 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 66473-14-1 N-butyl-4-nitrobenzenesulfonamide 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 100-01-6 4-nitro-aniline 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 63-74-1 sulfanilamide 
• 71-36-3 butan-1-ol 

Downstream Products

• 116691-42-0 N-Butyl-4-(8-hydroxy-quinolin-5-ylazo)-benzenesulfonamide 
• 155670-16-9 2-(6'-chlorobenzothiazol-2'-ylamino)-4-4-1-(n-butyl)sulphanilamido>>-6-chloro-s-triazine 
• 307990-37-0 (4-butyl-sulfamoylphenyl)carbamic acid phenyl ester 

Relevant articles and documents

Amino-(N-alkyl) benzsulfamide synthesis method

The invention discloses an amino-(N-alkyl) benzsulfamide synthesis method. The method comprises the steps of adding aminobenzenesul fonamide, an iridium complex catalyst, alkali, compound alcohol and the solvent tert-amyl alcohol into a reaction container for reaction lasting several hours at 120-150 DEG C, then reducing temperature to room temperature, conducting rotary evaporation to remove the solvent, and then conducting column separation to obtain the target compound. Commercial aminobenzenesul fonamide and nearly non-toxic compound alcohol are used as starting materials, only water is generated as reaction byproduct, and no environment harm is done; reaction atom economy is high.

Effective Recognition of Different Types of Amino Groups: From Aminobenzenesulfonamides to Amino-(N-alkyl)benzenesulfonamides via Iridium-Catalyzed N-Alkylation with Alcohols

(Chemical Equation Presented). A simple, highly efficient, and general strategy for the direct synthesis of amino-(N-alkyl)benzenesulfonamides has been accomplished via direct N-alkylation of aminobenzenesulfonamides bearing both different types of amino groups with alcohols as alkylating agents. Notably, this research exhibited the potential for the recognition of different types of amino groups in the N-alkylation of complex molecules with alcohols, facilitating the progress of the transition-metal-catalyzed "hydrogen autotransfer (or hydrogen-borrowing) process."

GLUCAGON ANTAGONISTS/INVERSE AGONISTS

A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any glucagon-