182913-48-0

Basic information

• Product Name: phenyl 5-(tert-butoxycarbonylaminoacetoxymethyl)-2-nitrophenoxyacetate
• Synonyms: phenyl 5-(tert-butoxycarbonylaminoacetoxymethyl)-2-nitrophenoxyacetate
• CAS NO: 182913-48-0
• Molecular Weight: 460.441
• Mol File: 182913-48-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: phenyl 5-(tert-butoxycarbonylaminoacetoxymethyl)-2-nitrophenoxyacetate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl 5-(tert-butoxycarbonylaminoacetoxymethyl)-2-nitrophenoxyacetate(182913-48-0)
• EPA Substance Registry System: phenyl 5-(tert-butoxycarbonylaminoacetoxymethyl)-2-nitrophenoxyacetate(182913-48-0)

Safety Data

• Hazardous Substances Data: 182913-48-0(Hazardous Substances Data)

Upstream product

• 182913-44-6 1-acetoxy-5-(tert-butoxycarbonylaminoacetoxymethyl)-2-nitrobenzene 
• 182913-38-8 5-methyl-2-nitrophenyl acetate 
• 700-38-9 2-nitro-5-methylphenol 
• 620-73-5 phenyl chloroacetate 
• 182913-46-8 5-(tert-butoxycarbonylaminoacetoxymethyl)-2-nitrophenol 

Relevant articles and documents

Synthesis of 5-(tert-Butoxycarbonylaminoacetoxymethyl)-2-nitrophenoxyacetic Acid

5-(tert-Butoxycarbonylaminoacetoxymethyl)-2-nitrophenoxyacetic acid was synthesized in seven steps starting from 5-methyl-2-nitrophenol. Its phenyl ester was selectively hydrolyzed with triethylamine in aqueous dioxane. 5-Hydroxymethyl-2-nitrophenoxyacetic acid was formed as by-product. Its formation was proved by independent synthesis from 1-acetoxy-5-bromomethyl-2-nitrobenzene. Experimental difficulties that arise along other routes to the target compound are discussed.