182934-27-6Relevant articles and documents
6-amino-1,8-dihydroimidazo[4,5-e][1,3]diazepin-4(5H)-one, a ring expanded analogue of guanine
Bridson, Peter K.,Huang, Huan,Lin, Xiaoyan
, p. 2257 - 2260 (2007/10/03)
The preparation of 6-amino-1,8-dihydroimidazo[4,5-e][1,3]diazepin-4(5H)-one (15), an analogue of guanine which has a seven-membered ring in place of the usual six-membered ring, is described. Cyclization to form the aminodiazepine ring involves reaction of amide and isothiourea groups in a suitably substituted imidazole precursor. The method is also shown to be applicable to the synthesis of an acyclonucleoside derivative (20).
