183019-41-2

Basic information

• Product Name: (2R,3S,4R,5R,6R)-6-((1R,2R)-3-Acetoxy-1,2-dihydroxy-propyl)-5-acetylamino-2-fluoro-4-hydroxy-3-phenylsulfanyl-tetrahydro-pyran-2-carboxylic acid methyl ester
• Synonyms: (2R,3S,4R,5R,6R)-6-((1R,2R)-3-Acetoxy-1,2-dihydroxy-propyl)-5-acetylamino-2-fluoro-4-hydroxy-3-phenylsulfanyl-tetrahydro-pyran-2-carboxylic acid methyl ester
• CAS NO: 183019-41-2
• Molecular Weight: 475.492
• Mol File: 183019-41-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S,4R,5R,6R)-6-((1R,2R)-3-Acetoxy-1,2-dihydroxy-propyl)-5-acetylamino-2-fluoro-4-hydroxy-3-phenylsulfanyl-tetrahydro-pyran-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,4R,5R,6R)-6-((1R,2R)-3-Acetoxy-1,2-dihydroxy-propyl)-5-acetylamino-2-fluoro-4-hydroxy-3-phenylsulfanyl-tetrahydro-pyran-2-carboxylic acid methyl ester(183019-41-2)
• EPA Substance Registry System: (2R,3S,4R,5R,6R)-6-((1R,2R)-3-Acetoxy-1,2-dihydroxy-propyl)-5-acetylamino-2-fluoro-4-hydroxy-3-phenylsulfanyl-tetrahydro-pyran-2-carboxylic acid methyl ester(183019-41-2)

Safety Data

• Hazardous Substances Data: 183019-41-2(Hazardous Substances Data)

Upstream product

• 146815-46-5 (2R,3S,4R,5S,6R)-4-Acetoxy-5-acetylamino-2-fluoro-3-phenylsulfanyl-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 120104-58-7 (2S,3S,4R,5S,6R)-4-Acetoxy-5-acetylamino-2-chloro-3-phenylsulfanyl-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 75-36-5 acetyl chloride 
• 146815-47-6 (2R,3S,4R,5R,6R)-5-Acetylamino-2-fluoro-4-hydroxy-3-phenylsulfanyl-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester 

Relevant articles and documents

Simple construction of Neu5Ac(α2-8)Neu5Ac and total synthesis of ganglioside GD3

Glycosylation of an 8-unprotected sialyl fluoride 16 with 2β-chloro-3β-phenylthio-Neu5Ac 2 gave the desired α-disialate 23. Subsequent glycosylation of a thiolactoside 19 with the disialyl fluoride 23 gave the tetrasaccharide 28. Synthesis of GD3 1 was realized by condensation of the tetrasaccharide 28 with azidosphingosine 31, following our previously reported GM3 synthesis procedure.