183121-03-1

Basic information

• Product Name: N-[(2S)-3-benzoylthio-2-methylpropionyl]-S-(4-dimethylamino)benzyl-L-cysteine
• Synonyms: N-[(2S)-3-benzoylthio-2-methylpropionyl]-S-(4-dimethylamino)benzyl-L-cysteine
• CAS NO: 183121-03-1
• Molecular Weight: 460.618
• Mol File: 183121-03-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[(2S)-3-benzoylthio-2-methylpropionyl]-S-(4-dimethylamino)benzyl-L-cysteine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(2S)-3-benzoylthio-2-methylpropionyl]-S-(4-dimethylamino)benzyl-L-cysteine(183121-03-1)
• EPA Substance Registry System: N-[(2S)-3-benzoylthio-2-methylpropionyl]-S-(4-dimethylamino)benzyl-L-cysteine(183121-03-1)

Safety Data

• Hazardous Substances Data: 183121-03-1(Hazardous Substances Data)

Upstream product

• 183121-49-5 N-tert-butoxycarbonyl-S-(4-dimethylamino)benzyl-L-cysteine 
• 1703-46-4 N,N-dimethyl-4-hydroxymethylaniline 
• 72679-02-8 (2S)-3-(benzoylthio)-2-methylpropionic acid 

Downstream Products

• 183121-23-5 SA₆₅₄₁ 

Relevant articles and documents

Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors

We studied synthetic modifications of N-mercaptoacylamino acid derivatives to develop a new class of leukotriene A4 (LTA4) hydrolase inhibitors. S-(4-Dimethylamino)benzyl-l-cysteine derivative 2a (SA6541) showed inhibitory activity against LTA4 hydrolase (IC50, 270 nM) and selectivity over other metallopeptidases except angiotensin-converting enzyme (ACE, IC50, 520 nM). Modification at the para-substituent of the phenyl ring of compound 2a improved LTA4 hydrolase inhibitory activity as well as selectivity over ACE. Finally, we obtained S-(4-cyclohexyl)benzy-l-cysteine derivatives 11l and 16i as potent and selective LTA4 hydrolase inhibitors.