183129-88-6Relevant articles and documents
Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720
Lu, Xuequan,Sun, Chaode,Valentine, William J.,Shuyu,Liu, Jianxiong,Tigyi, Gabor,Bittman, Robert
supporting information; experimental part, p. 3192 - 3195 (2009/09/30)
The first enantioselective synthesis of chiral isosteric phosphonate analogues of FTY720 is described. One of these analogues, FTY720-(E)- vinylphosphonate (S)-5, but not its R enantiomer, elicited a potent antiapoptotic effect in intestinal epithelial ce