18328-11-5Relevant articles and documents
An Improved Preparation of Tris(ethylenedioxyboryl)methane, a Reagent for the Homologation of Aldehydes and Ketones
Schummer, Dietmar,Hoefle, Gerhard
, p. 11219 - 11222 (1995)
The preparation of tris(ethylenedioxyboryl)methane (2), the reagent for the only known homologation of aldehydes and ketones under non-acidic conditions, was improved by avoiding the difficult isolation of the intermediate tris(dimethoxyboryl)methane (1) and by direct crystallization of 2.
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Kumler et al.
, p. 1463,1466 (1950)
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Intramolecular Aromatic Cyclizations of Alkenyliodonium Tetrafluoroborates
Ochiai, Masahito,Takaoka, Yoshikazu,Sumi, Kenzo,Nagao, Yoshimitsu
, p. 1382 - 1384 (1986)
1,2-Dihydronaphthalene and 2H-chromene derivatives have been synthesized by thermal intramolecular cyclizations of alkenyliodonium tetrafluoroborates under mild reaction conditions.
Ligand-controlled cobalt-catalyzed remote hydroboration and alkene isomerization of allylic siloxanes
Huang, Jiaxin,Li, Jie,Yang, Wen,Zhang, Kezhuo,Zhao, Pei,Zhao, Wanxiang
supporting information, p. 302 - 305 (2022/01/03)
The Co-catalyzed remote hydroboration and alkene isomerization of allylic siloxanes were realized by a ligand-controlled strategy. The remote hydroboration with dcype provided borylethers, while xantphos favored the formation of silyl enol ethers.
Novel monoacylglycerol lipase inhibitor as well as preparation method and application thereof
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Paragraph 0246-0248, (2021/02/10)
The invention discloses a novel monoacylglycerol lipase inhibitor as well as a preparation method and application thereof. Specifically, the invention provides a compound shown as a formula I, or a pharmaceutically acceptable salt, a stereoisomer, or a deuterated derivative thereof. Experimental results show that the compound provided by the invention can effectively inhibit MAGL activity, can beused for preparing an MAGL inhibitor and preparing medicines for preventing and/or treating diseases (including endometrial cancer, colorectal cancer, liver cancer, breast cancer, ovarian cancer, neurodegenerative diseases and the like) related to abnormal MAGL activity, and has a wide application prospect.
Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity
Bernstein, Peter R.,Dang, Xiawei,Devanathan, Sriram,Dorn, Gerald W.,Franco, Antonietta,Fu, Lijun,Walters, Daniel,Williams, Sidney B.
, p. 12506 - 12524 (2021/09/11)
Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small molecule mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach. The first-in-c