183322-19-2 Usage
Description
4-Chloro-6-(2-chloroethoxy)-7-(2-methoxyethoxy)quinazoline, with the CAS number 183322-19-2, is an off-white solid compound that is primarily used in organic synthesis. It is a derivative of quinazoline, a heterocyclic compound with a wide range of applications in various industries due to its unique chemical properties.
Uses
Used in Organic Synthesis:
4-Chloro-6-(2-chloroethoxy)-7-(2-methoxyethoxy)quinazoline is used as a synthetic intermediate for the development of various organic compounds. Its unique structure allows it to be a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-chloro-6-(2-chloroethoxy)-7-(2-methoxyethoxy)quinazoline is used as a key intermediate in the synthesis of novel drug candidates. Its chemical properties make it a valuable component in the development of new medications with potential therapeutic applications.
Used in Agrochemical Industry:
4-Chloro-6-(2-chloroethoxy)-7-(2-methoxyethoxy)quinazoline is also utilized in the agrochemical industry for the synthesis of new pesticides and other crop protection agents. Its unique chemical structure contributes to the development of innovative products with improved efficacy and selectivity.
Used in Chemical Research:
In the field of chemical research, 4-chloro-6-(2-chloroethoxy)-7-(2-methoxyethoxy)quinazoline serves as a valuable compound for studying various reaction mechanisms and exploring new synthetic routes. Its unique properties make it an interesting subject for academic and industrial research.
Check Digit Verification of cas no
The CAS Registry Mumber 183322-19-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,3,2 and 2 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 183322-19:
(8*1)+(7*8)+(6*3)+(5*3)+(4*2)+(3*2)+(2*1)+(1*9)=122
122 % 10 = 2
So 183322-19-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H14Cl2N2O3/c1-18-4-5-20-12-7-10-9(13(15)17-8-16-10)6-11(12)19-3-2-14/h6-8H,2-5H2,1H3
183322-19-2Relevant articles and documents
New synthetic route of two active isomeric metabolites of erlotinib and their bioactivity studies against several tumor cell lines
Li, Hanqing,Li, Mengyao,Li, Zaiquan,Li, Liang,Bi, Shanshan,Deng, Chenhui,Chen, Rui,Zhou, Tianyan,Lu, Wei
, p. 1709 - 1714 (2011)
The synthesis and differential antiproliferative activity of two active isomeric metabolites of erlotinib were investigated. This synthetic process had demonstrated to avoid the unstable 4-chloroquinazoline intermediates and long procedures. New intermedi
Isolation of highly pure erlotinib hydrochloride by recrystallization after nucleophilic substitution of an impurity with piperazine
Zhang, Gengzhen,Zha, Linlin
, p. 2303 - 2309 (2013/07/26)
Optimized synthesis and purification of erlotinib hydrochloride (N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazoline-4-amine hydrochloride) were studied. Highly polar piperazine was used in a nucleophilic substitution reaction with the chlorinated intermediate byproduct N-(3-ethynylphenyl)-6(2- chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. As a result, N-(3-ethynylphenyl)-6(2-chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride was completely transformed to N-(3-ethynylphenyl)-6(2- piperzinoethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. The polarity of N-(3-ethynylphenyl)-6(2-piperzinoethoxy)-7-(2-methoxyethoxy) quinazolin-4-amine hydrochloride was changed, and its molecule was enlarged. It was easy to remove this larger, more polar, compound by recrystallization. Highly pure erlotinib hydrochloride was obtained with low impurity content (99.9 %.