183365-33-5

Basic information

• Product Name: Acetamide, N-[4-[2-[4-[(4,5-dihydro-2-thiazolyl)amino]phenyl]ethyl]-2-thiazolyl]-
• CAS NO: 183365-33-5
• Molecular Formula: C16H18N4OS2
• Molecular Weight: 346.477
• Mol File: 183365-33-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-[2-[4-[(4,5-dihydro-2-thiazolyl)amino]phenyl]ethyl]-2-thiazolyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-[2-[4-[(4,5-dihydro-2-thiazolyl)amino]phenyl]ethyl]-2-thiazolyl]-(183365-33-5)
• EPA Substance Registry System: Acetamide, N-[4-[2-[4-[(4,5-dihydro-2-thiazolyl)amino]phenyl]ethyl]-2-thiazolyl]-(183365-33-5)

Safety Data

• Hazardous Substances Data: 183365-33-5(Hazardous Substances Data)

Upstream product

• 737822-88-7 N-{4-[(Z)-2-(4-nitrophenyl)ethenyl]-1,3-thiazol-2-yl}acetamide 
• 16444-13-6 N-(4-formyl-1,3-thiazol-2-yl)acetamide 
• 2767-70-6 (p-nitrobenzyl)triphenylphosphonium bromide 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 51307-38-1 N-[4-(hydroxymethyl)-1,3-thiazol-2-yl]acetamide 
• 111608-67-4 [2-(acetylamino)-1,3-thiazol-4-yl]methyl acetate 
• 19975-56-5 2-methylsulfanyl-4,5-dihydrothiazoline 
• 183365-29-9 N-{4-(2-(4-aminophenyl)ethyl)-1,3-thiazol-2-yl}acetamide 

Relevant articles and documents

Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema

Vascular adhesion protein-1 (VAP-1), an amine oxidase that is also known as a semicarbazide-sensitive amine oxidase (SSAO), is present in particularly high levels in human plasma, and is considered a potential therapeutic target for various inflammatory diseases, including diabetes complications such as macular edema. In our VAP-1 inhibitor program, structural modifications following high-throughput screening (HTS) of our compound library resulted in the discovery that thiazole derivative 10, which includes a guanidine group, shows potent human VAP-1 inhibitory activity (IC50 of 230 nM; rat IC 50 of 14 nM). Moreover, compound 10 exhibited significant inhibitory effects on ocular permeability in STZ-induced diabetic rats.