183428-90-2 Usage
Description
6-AMINO-2-METHYLNICOTINONITRILE, also known as 6-Amino-3-cyano-2-methylpyridine, is a versatile nitrile building block with significant applications in various fields, particularly in proteomics research and synthesis. Its unique chemical structure, featuring an amino group, a cyano group, and a methyl group attached to a pyridine ring, endows it with distinct properties that make it a valuable compound for scientific exploration and development.
Uses
Used in Proteomics Research:
6-AMINO-2-METHYLNICOTINONITRILE is used as a nitrile building block for proteomics research, enabling the study and analysis of proteins and their interactions within biological systems. Its presence in this field aids in the development of novel methods for protein identification, quantification, and characterization, which are crucial for understanding complex biological processes and advancing our knowledge of diseases and their underlying mechanisms.
Used in Synthesis:
6-AMINO-2-METHYLNICOTINONITRILE is also utilized as a key intermediate in the synthesis of various organic compounds and pharmaceuticals. Its unique structure allows for the formation of diverse chemical entities through reactions such as nucleophilic addition, substitution, and cyclization. This makes it a valuable component in the development of new drugs, agrochemicals, and other specialty chemicals that can address various challenges in healthcare, agriculture, and other industries.
Check Digit Verification of cas no
The CAS Registry Mumber 183428-90-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,4,2 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 183428-90:
(8*1)+(7*8)+(6*3)+(5*4)+(4*2)+(3*8)+(2*9)+(1*0)=152
152 % 10 = 2
So 183428-90-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H7N3/c1-5-6(4-8)2-3-7(9)10-5/h2-3H,1H3,(H2,9,10)
183428-90-2Relevant articles and documents
Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABAA receptor agonists
Petersen, Jette G.,S?rensen, Troels,Damgaard, Maria,Nielsen, Birgitte,Jensen, Anders A.,Balle, Thomas,Bergmann, Rikke,Fr?lund, Bente
, p. 404 - 416 (2014/08/05)
A series of 6-aminonicotinic acid analogues have been synthesized and pharmacologically characterized at native and selected recombinant GABA A receptors. 6-Aminonicotinic acid (3) as well as 2- and 4-alkylated analogues (9-11, 14-16) display low to mid-micromolar GABAAR binding affinities to native GABAA receptors (Ki 1.1-24 μM). The tetrahydropyridine analogue of 3 (22) shows low-nanomolar affinity (K i 0.044 μM) and equipotency as an agonist to GABA itself as well as the standard GABAA agonist isoguvacine. Cavities surrounding the core of the GABA binding pocket were predicted by molecular interaction field calculations and docking studies in a α1β 2γ2 GABAA receptor homology model, and were confirmed by affinities of substituted analogues of 3. The tight steric requirements observed for the remarkably few GABAAR agonists reported to date is challenged by our findings. New openings for agonist design are proposed which potentially could facilitate the exploration of different pharmacological profiles within the GABAAR area.
AZAINDOLE DERIVATIVES AS INHIBITORS OF P38 KINASE
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Page/Page column 73, (2010/11/24)
The invention is directed to methods to inhibit p38 kinase, preferably p38-α using compounds which are azaindoles wherein the azaindoles are coupled through an azacyclic linker to another cyclic moiety.
PYRAZINONE THROMBIN INHIBITORS
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, (2008/06/13)
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