183433-62-7

Basic information

• Product Name: 1-Propanone, 1-(2,6-dichloro-4-pyridinyl)-
• CAS NO: 183433-62-7
• Molecular Formula: C8H7Cl2NO
• Molecular Weight: 204.056
• Mol File: 183433-62-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 61.1 - 62.4 °C
• CAS DataBase Reference: 1-Propanone, 1-(2,6-dichloro-4-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(2,6-dichloro-4-pyridinyl)-(183433-62-7)
• EPA Substance Registry System: 1-Propanone, 1-(2,6-dichloro-4-pyridinyl)-(183433-62-7)

Safety Data

• Hazardous Substances Data: 183433-62-7(Hazardous Substances Data)

Usage

Type of compound

Pesticide and insecticide

Function

Controls a wide range of pests, including termites, ants, cockroaches, bed bugs, and spiders

Mechanism of action

Disrupts the energy production process in pests' cells, leading to their eventual death

Usage

Commonly used in agricultural and residential settings

Safety precautions

Follow recommended safety precautions to minimize risk of exposure to humans and non-target organisms

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 2402-78-0 2,6-dichloropyridine 
• 123-38-6 propionaldehyde 
• 2386-64-3 ethylmagnesium chloride 

Downstream Products

• 185319-20-4 1-(2,6-dichloropyridin-4-yl)ethan-1-one 
• 185135-84-6 4-((R)-1-Acetoxymethyl-1-hydroxy-propyl)-5-benzyloxymethyl-6-methoxy-pyridine-2-carboxylic acid propyl ester 
• 183433-68-3 5-Benzyloxymethyl-4-(2-ethyl-[1,3]dioxolan-2-yl)-6-methoxy-pyridine-2-carboxylic acid propyl ester 
• 183433-96-7 5-Benzyloxymethyl-4-((S)-1-formyl-1-hydroxy-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester 
• 183433-70-7 5-Benzyloxymethyl-6-methoxy-4-propionyl-pyridine-2-carboxylic acid propyl ester 
• 183433-72-9 5-Benzyloxymethyl-6-methoxy-4-(1-methylene-propyl)-pyridine-2-carboxylic acid propyl ester 
• 183433-67-2 3-Benzyloxymethyl-6-chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridine 
• 183434-02-8 propyl (S)-4-ethyl-3,4,7,8-tetrahydro-4-hydroxy-3,8-dioxo-1H-pyrano[3,4-c] pyridine-6-carboxylate 
• 183433-66-1 [6-Chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridin-3-yl]-methanol 
• 183433-65-0 6-Chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridine-3-carbaldehyde 
• 183433-75-2 5-Benzyloxymethyl-4-((S)-1-hydroxy-1-hydroxymethyl-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester 
• 183433-74-1 5-Benzyloxymethyl-4-(1-hydroxy-1-hydroxymethyl-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester 
• 97682-44-5 irinotecan 
• 86639-52-3 7-ethyl-10-hydroxycamptothecin 

Relevant articles and documents

Pyridine substituted chalcone type compound or medicinal salt thereof and preparation method and application thereof

The invention discloses a pyridine substituted chalcone type compound with a structure as shown in a general formula I or a medicinal salt thereof, and also discloses a preparation method and application of the compound or the medicinal salt thereof. The compound or the medicinal salt thereof disclosed by the invention has small toxic or side effects and strong water solubility, is not easy to generate drug resistance, can effectively inhibit the aggregation of tubulin, has stronger anti-tumor activity in vitro and in vivo, can ensure more stable metabolism and has good pharmacological prospects. The invention also discloses combined application of the pyridine substituted chalcone type compound or the medicinal salt thereof and a TACC3 inhibitor for effectively inhibiting the activity oftumor cells resistant to tubulin.

Practical asymmetric synthesis of (S)-4,ethyl-7,8-dihydro-4-hydroxy-1H- pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for the synthesis of Irinotecan and other camptothecin analogs

A practical asymmetric synthesis of (S) 4-ethyl-7,8-dihydro-4-hydroxy- 1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione (1), a versatile intermediate for the synthesis of camptothecin analogs, was developed. Commercially available citrazinic acid is converted in four steps into the 2-chloro-6- methoxypyridine 5. An ortho-directed metalation followed by reaction with a formamide produces an aldehyde with the required 2,3,4,6-substituted pyridine (6) with high regioselectivity. After refunctionalization of the aldehyde, the chloropyridine is converted into an ester by a facile palladium-mediated carbonylation reaction. Wittig reaction and racemic osmylation produce the diol 16 which is resolved by an efficient lipase resolution to an ee > 99%, and a one-pot recycle of the unwanted diol enantiomer was developed. A series of high-yielding oxidation and deprotection steps convert (S)-16 into the pyridone 25, which is then converted into 1 with an ee > 99.6%.