183434-00-6 Usage
Description
(S)-4-Ethyl-4-hydroxy-8-Methoxy-3-oxo-3,4-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylic acid propyl ester is a complex chemical compound characterized by its unique molecular structure. It features an ethyl group, a hydroxy group, a methoxy group, and a carboxylic acid group, along with a propyl ester group, which indicates its ester derivative nature from propyl alcohol. (S)-4-Ethyl-4-hydroxy-8-Methoxy-3-oxo-3,4-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylic acid propyl ester may hold potential applications in various fields such as pharmaceuticals and organic synthesis, given its distinct structural attributes. However, it is crucial to exercise caution when handling and utilizing this compound, as its properties and possible impacts on biological systems are not yet fully understood.
Uses
Used in Pharmaceutical Industry:
(S)-4-Ethyl-4-hydroxy-8-Methoxy-3-oxo-3,4-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylic acid propyl ester is used as a potential pharmaceutical candidate for [application reason] due to its unique structural features and functional groups.
Used in Organic Synthesis:
In the field of organic synthesis, (S)-4-Ethyl-4-hydroxy-8-Methoxy-3-oxo-3,4-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylic acid propyl ester is used as a key intermediate or building block for [application reason], taking advantage of its complex molecular structure and functional groups.
(Note: The application reasons are not provided in the materials, so they are left blank. They should be filled in with the specific reasons for using this compound in the respective industries.)
Check Digit Verification of cas no
The CAS Registry Mumber 183434-00-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,4,3 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 183434-00:
(8*1)+(7*8)+(6*3)+(5*4)+(4*3)+(3*4)+(2*0)+(1*0)=126
126 % 10 = 6
So 183434-00-6 is a valid CAS Registry Number.
183434-00-6Relevant articles and documents
Practical asymmetric synthesis of (S)-4,ethyl-7,8-dihydro-4-hydroxy-1H- pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for the synthesis of Irinotecan and other camptothecin analogs
Henegar,Ashford,Baughman,Sih,Gu
, p. 6588 - 6597 (2007/10/03)
A practical asymmetric synthesis of (S) 4-ethyl-7,8-dihydro-4-hydroxy- 1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione (1), a versatile intermediate for the synthesis of camptothecin analogs, was developed. Commercially available citrazinic acid is converted in four steps into the 2-chloro-6- methoxypyridine 5. An ortho-directed metalation followed by reaction with a formamide produces an aldehyde with the required 2,3,4,6-substituted pyridine (6) with high regioselectivity. After refunctionalization of the aldehyde, the chloropyridine is converted into an ester by a facile palladium-mediated carbonylation reaction. Wittig reaction and racemic osmylation produce the diol 16 which is resolved by an efficient lipase resolution to an ee > 99%, and a one-pot recycle of the unwanted diol enantiomer was developed. A series of high-yielding oxidation and deprotection steps convert (S)-16 into the pyridone 25, which is then converted into 1 with an ee > 99.6%.
