183500-69-8

Basic information

• Product Name: tert-butyl 4-(3-chlorophenyl)-3-oxopiperazine-1-carboxylate
• Synonyms: tert-butyl 4-(3-chlorophenyl)-3-oxopiperazine-1-carboxylate
• CAS NO: 183500-69-8
• Molecular Weight: 310.78
• Mol File: 183500-69-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(3-chlorophenyl)-3-oxopiperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(3-chlorophenyl)-3-oxopiperazine-1-carboxylate(183500-69-8)
• EPA Substance Registry System: tert-butyl 4-(3-chlorophenyl)-3-oxopiperazine-1-carboxylate(183500-69-8)

Safety Data

• Hazardous Substances Data: 183500-69-8(Hazardous Substances Data)

Upstream product

• 108-37-2 1-bromo-3-chlorobenzene 
• 76003-29-7 4-(t-butyloxycarbonyl)piperazin-2-one 
• 183500-68-7 N-[2-(tert-butoxycarbamoyl)ethyl]-N-(3-chlorophenyl)-2-chloroacetamide 

Downstream Products

• 183500-70-1 1-(3-chlorophenyl)-2-piperazinone 
• 183500-94-9 1-(3-chlorophenyl)-2-piperazinone hydrochloride 

Relevant articles and documents

QUATERNARY LACTAM COMPOUND AND PHARMACEUTICAL USE THEREOF

A quaternary lactam compound of formula (I). The compound is used in the manufacture of a medicament for the treatment and/or prevention of thrombotic or thromboembolic disorders.

Method of treating cancer

The present invention relates to methods of treating cancer using a combination of a compound which is a PSA conjugate and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is a PSA conjugate and a compound which is a inhibitor of prenyl-protein transferase. The invention also relates to methods of preparing such compositions.

Inhibitors of prenyl-protein transferase

The present invention comprises piperazinone-containing compounds, which may be useful as inhibitors of prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.