183506-67-4

Basic information

• Product Name: Cyclo[(2S)-2-amino-8-oxodecanoyl-Ltryptophyl- L-isoleucyl-(2R)-2- piperidinecarbonyl]
• CAS NO: 183506-67-4
• Molecular Weight: 593.767
• Mol File: 183506-67-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cyclo[(2S)-2-amino-8-oxodecanoyl-Ltryptophyl- L-isoleucyl-(2R)-2- piperidinecarbonyl] (CAS DataBase Reference)
• NIST Chemistry Reference: Cyclo[(2S)-2-amino-8-oxodecanoyl-Ltryptophyl- L-isoleucyl-(2R)-2- piperidinecarbonyl] (183506-67-4)
• EPA Substance Registry System: Cyclo[(2S)-2-amino-8-oxodecanoyl-Ltryptophyl- L-isoleucyl-(2R)-2- piperidinecarbonyl] (183506-67-4)

Safety Data

• Hazardous Substances Data: 183506-67-4(Hazardous Substances Data)

Upstream product

• 183506-66-3 apicidin 

Relevant articles and documents

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases

It has been widely debated whether class IIa HDACs have catalytic deacetylase activity, and whether this plays any part in controlling gene expression. Herein, it has been demonstrated that class IIa HDACs isolated from mammalian cells are contaminated with other deacetylases, but can be prepared cleanly in Escherichia coli. These bacteria preparations have weak but measurable deacetylase activity. The low efficiency can be restored either by: mutation of an active site histidine to tyrosine, or by the use of a non-acetylated lysine substrate, allowing the development of assays to identify class IIa HDAC inhibitors.