183543-37-5Relevant articles and documents
A novel series of 2-aminotetralins with high affinity and selectivity for the dopamine D3 receptor
Boyfield, Izzy,Coldwell, Martyn C.,Hadley, Michael S.,Johnson, Christopher N.,Riley, Graham J.,Scott, Emma E.,Stacey, Rachel,Stemp, Geoffrey,Thewlis, Kevin M.
, p. 1995 - 1998 (2007/10/03)
A novel series of N-[4-(4-Phenylbenzoylamino)butyl]-1,2,3,4-tetrahydro-2-naphthylamines with high affinity and selectivity for the dopamine D3 receptor has been prepared. The 5-cyclopropylmethyloxy 3j, methanesulfonyloxy 3k and trifluoromethanesulfonyloxy 3l derivatives represent some of the highest affinity (pKi's 8.6-8.9) and most selective (200-320-fold) dopamine D3 receptor antagonists reported to date.