183677-02-3

Basic information

• Product Name: 2-(4-bromophenyl)thiophen-3-amine
• Synonyms: 2-(4-bromophenyl)thiophen-3-amine;3-ThiophenaMine, 2-(4-broMophenyl)-;2-(4-broMo-phenyl)-thiophen-3-yl aMine
• CAS NO: 183677-02-3
• Molecular Formula: C₁₀H₈BrNS
• Molecular Weight: 0
• Mol File: 183677-02-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-bromophenyl)thiophen-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)thiophen-3-amine(183677-02-3)
• EPA Substance Registry System: 2-(4-bromophenyl)thiophen-3-amine(183677-02-3)

Safety Data

• Hazardous Substances Data: 183677-02-3(Hazardous Substances Data)

Usage

Structure

A five-membered ring containing a sulfur atom, with a bromine atom and an amine group attached to a phenyl ring.

Class

Thiophene compounds

Applications

Potential uses in chemical synthesis and pharmaceutical research.

Fields

Organic chemistry and materials science.

Reasons for further research

To fully understand the potential uses and effects of 2-(4-bromophenyl)thiophen-3-amine.

Upstream product

• 851199-00-3 (tert-butoxy)-N-[2-(4-bromophenyl)(3-thiophenyl)]carboxamide 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 77143-76-1 ethyl α-bromo-4-bromophenylacetate 

Downstream Products

• 851199-01-4 2-(4-bromophenyl)-3-chlorothiophene 
• 916429-85-1 propane-2-sulfonic acid [2-(4-bromo-phenyl)-thiophen-3-yl]-amide 

Relevant articles and documents

A practical synthesis of biaryls via a thermal decarboxylative Pd-catalyzed cross-coupling reaction operating at moderate temperature

The palladium-catalyzed decarboxylative cross-coupling of aminothiophene carboxylate and 1-bromo-4-chlorobenzene to produce 3-amino-2-(4-chlorophenyl) thiophene (2) is described. The cross-coupling proceeds under relatively mild conditions using catalytic Pd(0) and TBAB. Through use of a mixed-solvent system of DMF and NMP, it was possible to operate the cross-coupling system at 80 °C. An assessment of carbon dioxide liberation, which provides insight into the reaction operating parameters, is also discussed.

PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS

The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.