183718-70-9 Usage
Biological Activity
arachidonoyl serinol is an amide bond-containing analogue of 2-arachidonoylglycerol, exhibited only weak cb1 receptor agonistic activity. 2-arachidonoyl glycerol (2-ag), a product of increased inositol phospholipid metabolism, is the natural endocannabinoid ligand for the cb1 receptor [1][2][3].cannabinoid receptor (cb1) was first identified in rat brain in 1988. n-arachidonoylethanolamine (anandamide) binds to the cannabinoid receptor and exhibits various cannabimimetic activities. anandamide inhibits calcium currents in n18 neuroblastoma cells, inhibits forskolin-stimulated adenylase cyclase activity, electrically evokes twitch response of the mouse vas deferens, and causes analgesia, hypothermia, hypoactivity, and catalepsy [3]. anandamide acts as a weak agonist and 2-arachidonoylglycerol may be an endogenous cannabinoid receptor agonist in nervous tissues [1].replacement of the sn-2 oxygen in the glycerol moiety of 2-ag with a nitrogen atom produces arachidonoyl serinol. in ng108-15 cells, arachidonoyl serinol induced a weak elevation of [ca2+]i [1][2].
Check Digit Verification of cas no
The CAS Registry Mumber 183718-70-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,7,1 and 8 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 183718-70:
(8*1)+(7*8)+(6*3)+(5*7)+(4*1)+(3*8)+(2*7)+(1*0)=159
159 % 10 = 9
So 183718-70-9 is a valid CAS Registry Number.
183718-70-9Relevant articles and documents
A novel class of cationic and non-peptidic small molecules as hits for the development of antimicrobial agents
Jiménez, Aranza,García, Pablo,De La Puente, Sofia,Madrona, Andrés,Camarasa, María José,Pérez-Pérez, María-Jesús,Quintela, José-Carlos,García-del Portillo, Francisco,San-Félix, Ana
, (2018/07/10)
Cationic and non-peptide small molecules containing a total of six positive charges arranged on one side and a long aliphatic tail on the other have been synthesized and tested against Gram-positive and Gram-negative bacteria. The positive charges have be
