183801-13-0

Basic information

• Product Name: 2-Propynal, 3-[4-(trifluoromethyl)phenyl]-
• CAS NO: 183801-13-0
• Molecular Formula: C10H5F3O
• Molecular Weight: 198.144
• Mol File: 183801-13-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Propynal, 3-[4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propynal, 3-[4-(trifluoromethyl)phenyl]-(183801-13-0)
• EPA Substance Registry System: 2-Propynal, 3-[4-(trifluoromethyl)phenyl]-(183801-13-0)

Safety Data

• Hazardous Substances Data: 183801-13-0(Hazardous Substances Data)

Upstream product

• 87413-09-0 Dess-Martin periodane 
• 173546-21-9 3-(4-trifluoromethylphenyl)prop-2-yn-1-ol 
• 455-13-0 4-Iodobenzotrifluoride 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 558-13-4 carbon tetrabromide 
• 68-12-2 N,N-dimethyl-formamide 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 131356-53-1 1-(2,2-dibromovinyl)-4-(trifluoromethyl)benzeney 
• 705-31-7 4-trifluoromethylphenylacetylene 
• 107-19-7 propargyl alcohol 

Downstream Products

• 1354628-22-0 6-(4-(trifluoromethyl)phenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine 

Relevant articles and documents

NHC-catalyzed enantioselective C2-functionalization of 3-hydroxychromenonesviaα,β-unsaturated acyl azoliums

A novel synthetic method for enantioselective C2-functionalization of 3-hydroxychromenones promoted by N-heterocyclic carbenesviathe formation of α,β-unsaturated acyl azolium intermediates, which occurs with Coates-Claisen rearrangement is established. This synthetic strategy enabled the rapid assembly of enantiomerically enriched δ-hydroxychromenone-derived esters/amides under mild conditions with good to excellent yields and broad substrate scope.

Gold-Catalyzed Synthesis of 2,5-Disubstituted Oxazoles from Carboxamides and Propynals

2,5-Disubstituted oxazoles are synthesized by oxidative gold catalysis. In contrast to a reported procedure that delivers 2,4-disubstituted oxazoles starting from terminal alkynes, a switch in selectivity towards a 2,5-disubstitution is achieved by the use of propynals as starting materials. In the new reaction, the key intermediate is formed by the nucleophilic attack of the carboxamide onto a gold carbenoid, and then condensates with the more electrophilic aldehyde moiety already present in the substrate and not with the ketone that is derived from the oxygen donor. This new cyclization mode introduces a new carbonyl moiety as substituent at the 2,5-disubstituted oxazole, an attractive motive that can be found in bioactive compounds or be used for further derivatizations. (Figure presented.).

Combining silver- and organocatalysis: An enantioselective sequential catalytic approach towards pyrano-annulated pyrazoles

A one-pot asymmetric Michael addition/hydroalkoxylation sequence, catalyzed by a sequential catalytic system consisting of a squaramide and a silver salt, provides a new series of chiral pyrano-annulated pyrazole derivatives in excellent yields (up to 95%) and high enantioselectivities (up to 97% ee).